Fluoroscopic tumor tracking for image-guided lung cancer radiotherapy

doi:10.1088/0031-9155/54/4/011

CORC > 北京大学 > 信息科学技术学院

	Fluoroscopic tumor tracking for image-guided lung cancer radiotherapy
	Lin, Tong ; Cervino, Laura I. ; Tang, Xiaoli ; Vasconcelos, Nuno ; Jiang, Steve B.
刊名	物理学在医学与生物学中应用
	2009
关键词	DYNAMIC MULTILEAF COLLIMATOR IMPLANTED FIDUCIAL MARKERS RADIATION-THERAPY SMART REAL-TIME MOVEMENT COMPENSATION RESPIRATORY MOTION FEASIBILITY RADIOSURGERY MACHINES ACCURACY
DOI	10.1088/0031-9155/54/4/011
英文摘要	Accurate lung tumor tracking in real time is a keystone to image-guided radiotherapy of lung cancers. Existing lung tumor tracking approaches can be roughly grouped into three categories: (1) deriving tumor position from external surrogates; (2) tracking implanted fiducial markers fluoroscopically or electromagnetically; (3) fluoroscopically tracking lung tumor without implanted fiducial markers. The first approach suffers from insufficient accuracy, while the second may not be widely accepted due to the risk of pneumothorax. Previous studies in fluoroscopic markerless tracking are mainly based on template matching methods, which may fail when the tumor boundary is unclear in fluoroscopic images. In this paper we propose a novel markerless tumor tracking algorithm, which employs the correlation between the tumor position and surrogate anatomic features in the image. The positions of the surrogate features are not directly tracked; instead, we use principal component analysis of regions of interest containing them to obtain parametric representations of their motion patterns. Then, the tumor position can be predicted from the parametric representations of surrogates through regression. Four regression methods were tested in this study: linear and two-degree polynomial regression, artificial neural network (ANN) and support vector machine (SVM). The experimental results based on fluoroscopic sequences of ten lung cancer patients demonstrate a mean tracking error of 2.1 pixels and a maximum error at a 95% confidence level of 4.6 pixels (pixel size is about 0.5 mm) for the proposed tracking algorithm.; Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); 46; ARTICLE; 4; 981-992; 54
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/292024]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Lin, Tong,Cervino, Laura I.,Tang, Xiaoli,et al. Fluoroscopic tumor tracking for image-guided lung cancer radiotherapy[J]. 物理学在医学与生物学中应用,2009.
APA	Lin, Tong,Cervino, Laura I.,Tang, Xiaoli,Vasconcelos, Nuno,&Jiang, Steve B..(2009).Fluoroscopic tumor tracking for image-guided lung cancer radiotherapy.物理学在医学与生物学中应用.
MLA	Lin, Tong,et al."Fluoroscopic tumor tracking for image-guided lung cancer radiotherapy".物理学在医学与生物学中应用 (2009).