Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of   Multiple Inputs

doi:10.1021/am5036994

CORC > 北京大学 > 信息科学技术学院

	Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs
	Yang, Jing ; Dong, Chen ; Dong, Yafei ; Liu, Shi ; Pan, Linqiang ; Zhang, Cheng
刊名	acs applied materials interfaces
	2014
关键词	fluorescent beacon binding-induced strand displacement DNA self-assembly gold nanoparticle logical computing DNA STRAND DISPLACEMENT G-QUADRUPLEX DNAZYME COMPUTATION CIRCUITS GATES NANOSTRUCTURES CASCADES SENSORS
DOI	10.1021/am5036994
英文摘要	Recently, the toehold-mediated DNA strand displacement reaction has been widely used in detecting molecular signals. However, traditional strand displacement, without cooperative signaling among DNA inputs, is insufficient for the design of more complicated nanodevices. In this work, a logic computing system is established using the cooperative "binding-induced" mechanism, based on the AuNP-based beacons, in which five kinds of multiple-input logic gates have been constructed. This system can recognize DNA and protein streptavidin simultaneously. Finally, the manipulations of the logic system are also demonstrated by controlling programmed conjugate DNA/AuNP clusters. This study provides the possibility of detecting multiple input signals and designing complex nanodevices that can be potentially applied to the detection of multiple molecular targets and the construction of large-scale DNA-based computation.; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; SCI(E); EI; 2; ARTICLE; yangjing369@gmail.com; lqpan@mail.hust.edu.cn; zhangcheng369@pku.edu.cn; 16; 14486-14492; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/209831]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Yang, Jing,Dong, Chen,Dong, Yafei,et al. Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs[J]. acs applied materials interfaces,2014.
APA	Yang, Jing,Dong, Chen,Dong, Yafei,Liu, Shi,Pan, Linqiang,&Zhang, Cheng.(2014).Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs.acs applied materials interfaces.
MLA	Yang, Jing,et al."Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs".acs applied materials interfaces (2014).