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	Fabrication of Bulk Titanium Out-of-plane Microneedles
	Zhao, Gang ; Li, Wen ; Tang, Guanrong ; Chen, Jing
	2009
关键词	bulk titanium microneedles out-of-plane wet etching titania DRUG-DELIVERY
英文摘要	In this study, isotropic wet etching technology has been developed to achieve the pyramidal needle structures on one side polished chemical pure titanium substrate. Different etchants, mask materials and substrate materials combinations were investigated respectively for process optimization. A steady etch rate in excess of 2 mu m/min has been achieved with sputtered Ni mask. For the first time, bulk titanium out-of-plane microneedle array was fabricated with excellent sharpness. By aqueous oxidation, nanostructured porous titania was generated on the surface of the microneedle, which not only enhanced the biocompatibility of titanium devices and implants but also provided an approach for drug loading. With its high fracture toughness, high strength, and excellent biocompatibility, the bulk titanium out-of-plane microneedles may play an important role in the future clinical applications.; Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; EI; CPCI-S(ISTP); 1
语种	英语
DOI标识	10.1109/NEMS.2009.5068611
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153268]
专题	信息科学技术学院
推荐引用方式 GB/T 7714	Zhao, Gang,Li, Wen,Tang, Guanrong,et al. Fabrication of Bulk Titanium Out-of-plane Microneedles. 2009-01-01.

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