Chronic exposure to air pollution particles increases the risk of   obesity and metabolic syndrome: findings from a natural experiment in   Beijing

doi:10.1096/fj.201500142

CORC > 北京大学 > 环境科学与工程学院

	Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing
	Wei, Yongjie ; Zhang, Junfeng ; Li, Zhigang ; Gow, Andrew ; Chung, Kian Fan ; Hu, Min ; Sun, Zhongsheng ; Zeng, Limin ; Zhu, Tong ; Jia, Guang ; Li, Xiaoqian ; Duarte, Marlyn ; Tang, Xiaoyan
刊名	FASEB JOURNAL
	2016
关键词	chronic inflammation metabolic dysfunction particulate matter TUMOR-NECROSIS-FACTOR INSULIN-RESISTANCE ADIPOSE-TISSUE MACROPHAGE INFILTRATION MOUSE MODEL INFLAMMATION ASSOCIATION INTERLEUKIN-10 PROTEIN UPDATE
DOI	10.1096/fj.201500142
英文摘要	Epidemiologic evidence suggests that air pollution is a risk factor for childhood obesity. Limited experimental data have shown that early-life exposure to ambient particles either increases susceptibility to diet-induced weight gain in adulthood or increases insulin resistance, adiposity, and inflammation. However, no data have directly supported a link between air pollution and non-diet-induced weight increases. In a rodent model, we found that breathing Beijing's highly polluted air resulted in weight gain and cardiorespiratory and metabolic dysfunction. Compared to those exposed to filtered air, pregnant rats exposed to unfiltered Beijing air were significantly heavier at the end of pregnancy. At 8 wk old, the offspring prenatally and postnatally exposed to unfiltered air were significantly heavier than those exposed to filtered air. In both rat dams and their offspring, after continuous exposure to unfiltered air we observed pronounced histologic evidence for both perivascular and peribronchial inflammation in the lungs, increased tissue and systemic oxidative stress, dyslipidemia, and an enhanced proinflammatory status of epididymal fat. Results suggest that TLR2/4-dependent inflammatory activation and lipid oxidation in the lung can spill over systemically, leading to metabolic dysfunction and weight gain.Wei, Y., Zhang, J., Li, Z., Gow, A., Chung, K. F., Hu, M., Sun, Z., Zeng, L., Zhu, T., Jia, G., Li, X., Duarte, M., Tang, X. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.; National Natural Science Foundation of China [21190051, 21477119]; State Key Joint Laboratory of Environment Simulation and Pollution Control [13K03ESPCP]; China Postdoctoral Science Foundation [201003010]; SCI(E); PubMed; ARTICLE; junfeng.zhang@duke.edu; xytang@pku.edu.cn; 6; 2115-2122; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434839]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Wei, Yongjie,Zhang, Junfeng,Li, Zhigang,et al. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing[J]. FASEB JOURNAL,2016.
APA	Wei, Yongjie.,Zhang, Junfeng.,Li, Zhigang.,Gow, Andrew.,Chung, Kian Fan.,...&Tang, Xiaoyan.(2016).Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.FASEB JOURNAL.
MLA	Wei, Yongjie,et al."Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing".FASEB JOURNAL (2016).