Inflammatory and Oxidative Stress Responses of Healthy Young Adults to   Changes in Air Quality during the Beijing Olympics

doi:10.1164/rccm.201205-0850OC

CORC > 北京大学 > 环境科学与工程学院

	Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics
	Huang, Wei ; Wang, Guangfa ; Lu, Shou-En ; Kipen, Howard ; Wang, Yuedan ; Hu, Min ; Lin, Weiwei ; Rich, David ; Ohman-Strickland, Pamela ; Diehl, Scott R. ; Zhu, Ping ; Tong, Jian ; Gong, Jicheng ; Zhu, Tong ; Zhang, Junfeng
刊名	美国呼吸道与危重症监护医学杂志
	2012
关键词	air pollution inflammation oxidative stress respiratory health the Beijing Olympics EXHALED BREATH CONDENSATE CORONARY-ARTERY-DISEASE NITRIC-OXIDE AMBIENT AIR ASTHMATIC-CHILDREN PARTICULATE MATTER PM2.5 EXPOSURE HEART-DISEASE DNA-DAMAGE POLLUTION
DOI	10.1164/rccm.201205-0850OC
英文摘要	Rationale: Unprecedented pollution control actions during the Beijing Olympics provided a quasi-experimental opportunity to examine biologic responses to drastic changes in air pollution levels. Objectives: To determine whether changes in levels of biomarkers reflecting pulmonary inflammation and pulmonary and systemic oxidative stress were associated with changes in air pollution levels in healthy young adults. Methods: We measured fractional exhaled nitric oxide, a number of exhaled breath condensate markers (H+, nitrite, nitrate, and 8-isoprostane), and urinary 8-hydroxy-2-deoxyguanosine in 125 participants twice in each of the pre- (high pollution), during(low pollution), and post-Olympic (high pollution) periods. We measured concentrations of air pollutants near where the participants lived and worked. We used mixed-effects models to estimate changes in biomarker levels across the three periods and to examine whether changes in biomarker levels were associated with changes in pollutant concentrations, adjusting for meteorologic parameters. Measurements and Main Results: From the pre- to the during-Olympic period, we observed significant and often large decreases (ranging from -4.5% to -72.5%) in levels of all the biomarkers. From the during-Olympic to the post-Olympic period, we observed significant and larger increases (48-360%) in levels of these same biomarkers. Moreover, increased pollutant concentrations were consistently associated with statistically significant increases in biomarker levels. Conclusions: These findings support the important role of oxidative stress and that of pulmonary inflammation in mediating air pollution health effects. The findings demonstrate the utility of novel and noninvasive biomarkers in the general population consisting largely of healthy individuals.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000312040600020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Critical Care Medicine; Respiratory System; SCI(E); PubMed; 45; ARTICLE; 11; 1150-1159; 186
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/324324]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Huang, Wei,Wang, Guangfa,Lu, Shou-En,et al. Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics[J]. 美国呼吸道与危重症监护医学杂志,2012.
APA	Huang, Wei.,Wang, Guangfa.,Lu, Shou-En.,Kipen, Howard.,Wang, Yuedan.,...&Zhang, Junfeng.(2012).Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics.美国呼吸道与危重症监护医学杂志.
MLA	Huang, Wei,et al."Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics".美国呼吸道与危重症监护医学杂志 (2012).