Personal exposure to particulate PAHs and anthraquinone and oxidative   DNA damages in humans

doi:10.1016/j.chemosphere.2010.08.055

CORC > 北京大学 > 环境科学与工程学院

	Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans
	Wei, Yongjie ; Han, In-Kyu ; Hu, Min ; Shao, Min ; Zhang, Junfeng ; Tang, Xiaoyan
刊名	chemosphere
	2010
关键词	Personal exposure 8 OHdG (8 hydroxydeoxyguanosine) PAHs Anthraquinone PM(2 5) Oxidative stress POLYCYCLIC AROMATIC-HYDROCARBONS DIESEL EXHAUST PARTICLES ENVIRONMENTAL AIR-POLLUTION OXYGEN SPECIES GENERATION SOURCE APPORTIONMENT ORGANIC-COMPOUNDS URINARY 8-HYDROXY-2&apos URBAN ATMOSPHERE EPITHELIAL-CELLS LUNG-CANCER -DEOXYGUANOSINE
DOI	10.1016/j.chemosphere.2010.08.055
英文摘要	Recent studies suggest that DNA oxidative damage be related to the chemical constituents of ambient particles The purpose of this study was to examine whether particulate polycyclic aromatic hydrocarbons (PAHs) and quinone-structure chemicals increase body burden of oxidative stress in human exposed to heavy traffic volume We recruited two nonsmoking security guards who worked at a university campus gate near a heavily trafficked road Each subject wore a personal air sampler for 24 h per day to estimate exposures to 24 PAHs and anthraquinone (AnQ) in PM(2) (5) Daily pre and post-work shift spot urines were collected for 29 d from each subject Urine samples were analyzed for 8 hydroxy 2' deoxyguanosine (8-OHdG) Additionally using 19 organic tracers other than 24 PAHs and AnQ a receptor source apportionment model of chemical mass balance was applied to determine the contributions of sources on the PM gasoline vehicle diesel vehicle coal burning vegetable debris cooking natural gas and biomass burning The relationship among urinary 8-OHdG individual PAH and AnQ was demonstrated as follows the average urinary concentration of 8-OHdG was increased more than three times after 8-h work-shift than those before the work shift All the 24 PAH and AnQ levels were positively and significantly associated with the post work urinary 8 OHdG The results from source apportionment suggest vehicular emission to be the dominant source of personal exposure to PM(2) (5) Our finding indicates that personal air exposures to 24 individual PAHs and AnQ originating from traffic emissions are important in increasing oxidative burdens in human body (C) 2010 Elsevier Ltd All rights reserved; Environmental Sciences; SCI(E); EI; PubMed; 37; ARTICLE; 10; 1280-1285; 81
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/158876]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Wei, Yongjie,Han, In-Kyu,Hu, Min,et al. Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans[J]. chemosphere,2010.
APA	Wei, Yongjie,Han, In-Kyu,Hu, Min,Shao, Min,Zhang, Junfeng,&Tang, Xiaoyan.(2010).Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans.chemosphere.
MLA	Wei, Yongjie,et al."Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans".chemosphere (2010).