Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for   a rural population from the North China Plain

doi:10.1007/s11356-014-3284-y

CORC > 北京大学 > 环境科学与工程学院

	Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain
	Yang, Qiaoyun ; Qiu, Xinghua ; Li, Ran ; Ma, Jin ; Li, Keqiu ; Li, Guang
刊名	environmental science and pollution research
	2015
关键词	PAH exposure Hydroxy-PAHs Oxidative stress MDA 8-OHdG Rural population North China Plain PERSISTENT ORGANIC POLLUTANTS WASTE RECYCLING SITE DIETARY EXPOSURE AIR-POLLUTION CANCER RISK 1-HYDROXYPYRENE DNA METABOLITES AMBIENT WORKERS
DOI	10.1007/s11356-014-3284-y
英文摘要	Polycyclic aromatic hydrocarbons (PAHs) belong to a class of ubiquitous pollutants and are possibly associated with adverse health effects. In this study, we aimed to assess PAH exposure by measuring the hydroxylated metabolites (hydroxy-PAHs) in urine samples of a rural population from the North China Plain and to explore the possible associations between PAH exposure and oxidative stress indicated by urinary malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). High levels of urinary hydroxy-PAHs were observed, with the geometric mean concentrations of 0.57, 2.2, 5.0, 7.0, and 16.6 mu g g(-1) creatinine for 1-hydroxypyrene, hydroxyphenanthrenes, hydroxyfluorenes, hydroxybiphenyls, and hydroxynaphthalenes, respectively. Particularly in the winter season, the exposures were 2.3-6.0-fold of those in the spring. Corresponding to PAH exposure, levels of urinary MDA were positively associated with hydroxy-PAHs after controlling for confounders in the linear regression models (p < 0.05). An estimation indicated 21.3-39.3 % increment of urinary MDA per one-fold increase of hydroxy-PAHs. In contrast, no significant correlation was found between urinary 8-OHdG and hydroxy-PAHs; alternatively, living at the e-waste recycling site was found a significant factor on this oxidative DNA damage. These results provide evidence on high PAH exposure and the induction of oxidative stress on lipid peroxidation for this rural population.; Environmental Sciences; SCI(E); 0; ARTICLE; xhqiu@pku.edu.cn; 3; 1760-1769; 22
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/158194]
专题	环境科学与工程学院
推荐引用方式 GB/T 7714	Yang, Qiaoyun,Qiu, Xinghua,Li, Ran,et al. Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain[J]. environmental science and pollution research,2015.
APA	Yang, Qiaoyun,Qiu, Xinghua,Li, Ran,Ma, Jin,Li, Keqiu,&Li, Guang.(2015).Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain.environmental science and pollution research.
MLA	Yang, Qiaoyun,et al."Polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress for a rural population from the North China Plain".environmental science and pollution research (2015).