Impaired glucose tolerance in first-episode drug-naive patients with   schizophrenia: relationships with clinical phenotypes and cognitive   deficits

doi:10.1017/S0033291716001902

CORC > 北京大学 > 心理与认知科学学院

	Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia: relationships with clinical phenotypes and cognitive deficits
	Chen, D. C. ; Du, X. D. ; Yin, G. Z. ; Yang, K. B. ; Nie, Y. ; Wang, N. ; Li, Y. L. ; Xiu, M. H. ; He, S. C. ; Yang, F. D. ; Cho, R. Y. ; Kosten, T. R. ; Soares, J. C. ; Zhao, J. P. ; Zhang, X. Y.
刊名	PSYCHOLOGICAL MEDICINE
	2016
关键词	Cognition drug-naive patients first-episode schizophrenia glycometabolism psychopathology TYPE-2 DIABETES-MELLITUS CHINESE HAN POPULATION INSULIN-RESISTANCE 2ND-GENERATION ANTIPSYCHOTICS IMPROVING COGNITION METABOLIC SYNDROME HEALTHY CONTROLS BRAIN STRUCTURE RISK METAANALYSIS
DOI	10.1017/S0033291716001902
英文摘要	Background. Schizophrenia patients have a higher prevalence of type 2 diabetes mellitus with impaired glucose tolerance (IGT) than normals. We examined the relationship between IGT and clinical phenotypes or cognitive deficits in first-episode, drug-naive (FEDN) Han Chinese patients with schizophrenia. Method. A total of 175 in-patients were compared with 31 healthy controls on anthropometric measures and fasting plasma levels of glucose, insulin and lipids. They were also compared using a 75 g oral glucose tolerance test and the homeostasis model assessment of insulin resistance (HOMA-IR). Neurocognitive functioning was assessed using the MATRICS Consensus Cognitive Battery (MCCB). Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). Results. Of the patients, 24.5% had IGT compared with none of the controls, and they also had significantly higher levels of fasting blood glucose and 2-h glucose after an oral glucose load, and were more insulin resistant. Compared with those patients with normal glucose tolerance, the IGT patients were older, had a later age of onset, higher waist or hip circumference and body mass index, higher levels of low-density lipoprotein and triglycerides and higher insulin resistance. Furthermore, IGT patients had higher PANSS total and negative symptom subscale scores, but no greater cognitive impairment except on the emotional intelligence index of the MCCB. Conclusions. IGT occurs with greater frequency in FEDN schizophrenia, and shows association with demographic and anthropometric parameters, as well as with clinical symptoms but minimally with cognitive impairment during the early course of the disorder.; National Natural Science Foundation of China [81371477]; Beijing Municipal Natural Science Foundation [7132063, 7072035]; NARSAD Independent Investigator Grant [20314]; Jiangsu Provincial Special Program of Medical Science - New Type Clinical Diagnosis and Treatment Project [BL2013018]; Suzhou Key Medical Center for Psychiatric Diseases [Szzx201509]; SCI(E); PubMed; SSCI; ARTICLE; xiang.y.zhang@uth.tmc.edu; 15; 3219-3230; 46
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/492976]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Chen, D. C.,Du, X. D.,Yin, G. Z.,et al. Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia: relationships with clinical phenotypes and cognitive deficits[J]. PSYCHOLOGICAL MEDICINE,2016.
APA	Chen, D. C..,Du, X. D..,Yin, G. Z..,Yang, K. B..,Nie, Y..,...&Zhang, X. Y..(2016).Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia: relationships with clinical phenotypes and cognitive deficits.PSYCHOLOGICAL MEDICINE.
MLA	Chen, D. C.,et al."Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia: relationships with clinical phenotypes and cognitive deficits".PSYCHOLOGICAL MEDICINE (2016).