Neuroplastic Correlates in the mPFC Underlying the Impairment of   Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to   Chronic Mild Stress during Adolescence

doi:10.1155/2017/9382797

CORC > 北京大学 > 心理与认知科学学院

	Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence
	Zhang, Yu ; Shao, Feng ; Wang, Qiong ; Xie, Xi ; Wang, Weiwen
刊名	NEURAL PLASTICITY
	2017
关键词	CHRONIC UNPREDICTABLE STRESS FORCED SWIMMING TEST ACTIVATED PROTEIN-KINASES MEDIAL PREFRONTAL CORTEX DEPRESSIVE-LIKE BEHAVIOR MATERNAL SEPARATION MAJOR DEPRESSION RESTRAINT STRESS SOCIAL-BEHAVIOR ANXIETY-LIKE
DOI	10.1155/2017/9382797
英文摘要	Using a valid chronic mild stress (CMS) model of depression, we found that adolescent (postnatal days [PND] 28-41) CMS induced transient alterations in anhedonia that did not persist into adulthood after a 3-week recovery period. Previously stressed adult rats exhibited more immobility/despair behaviors in the forced swimming test and a greater number of trials to reach criterion in the set-shifting task, suggesting the impaired ability to cope with stressors and the cognitive flexibility that allows adaptation to dynamic environments during adulthood. In addition, adult rat exposure to adolescent CMS had a relatively inhibited activation in ERK signaling and downstream protein expression of phosphorylated cAMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the medial prefrontal cortex. Further correlation analysis demonstrated that immobility and set-shifting performance were positively correlated with the inhibition of ERK signaling. These results indicated adolescent CMS can be used as an effective stressor to model an increased predisposition to adult depression.; National Natural Science Foundation of China [81471122, 31470988]; Chinese Academy of Sciences [KJZD-EW-L04]; CAS Key Laboratory of Mental Health, Institute of Psychology; SCI(E); ARTICLE
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/476386]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Yu,Shao, Feng,Wang, Qiong,et al. Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence[J]. NEURAL PLASTICITY,2017.
APA	Zhang, Yu,Shao, Feng,Wang, Qiong,Xie, Xi,&Wang, Weiwen.(2017).Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence.NEURAL PLASTICITY.
MLA	Zhang, Yu,et al."Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence".NEURAL PLASTICITY (2017).