The primary somatosensory cortex and the insula contribute differently   to the processing of transient and sustained nociceptive and   non-nociceptive somatosensory inputs

doi:10.1002/hbm.22922

CORC > 北京大学 > 心理与认知科学学院

	The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs
	Hu, Li ; Zhang, Li ; Chen, Rui ; Yu, Hongbo ; Li, Hong ; Mouraux, Andre
刊名	HUMAN BRAIN MAPPING
	2015
关键词	pain sustained brain responses functional magnetic resonance imaging (fMRI) operculo-insular cortex (OIC) anterior and mid-cingulate cortex (ACC and MCC) primary somatosensory cortex (S1) LASER-EVOKED-POTENTIALS ANTERIOR CINGULATE CORTEX PAIN PERCEPTION FUNCTIONAL-SIGNIFICANCE NEUROPATHIC PAIN STIMULATION RESPONSES HUMANS BRAIN SYSTEM
DOI	10.1002/hbm.22922
英文摘要	Transient nociceptive stimuli elicit consistent brain responses in the primary and secondary somatosensory cortices (S1, S2), the insula and the anterior and mid-cingulate cortex (ACC/MCC). However, the functional significance of these responses, especially their relationship with sustained pain perception, remains largely unknown. Here, using functional magnetic resonance imaging, we characterize the differential involvement of these brain regions in the processing of sustained nociceptive and non-nociceptive somatosensory input. By comparing the spatial patterns of activity elicited by transient (0.5 ms) and long-lasting (15 and 30 s) stimuli selectively activating nociceptive or non-nociceptive afferents, we found that the contralateral S1 responded more strongly to the onset of non-nociceptive stimulation as compared to the onset of nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. Similarly, the anterior insula responded more strongly to the onset of nociceptive stimulation as compared to the onset of non-nociceptive stimulation and the sustained phases of nociceptive and non-nociceptive stimulation. This suggests that S1 is specifically sensitive to changes in incoming non-nociceptive input, whereas the anterior insula is specifically sensitive to changes in incoming nociceptive input. Second, we found that the MCC responded more strongly to the onsets as compared to the sustained phases of both nociceptive and non-nociceptive stimulation, suggesting that it could be involved in the detection of change regardless of sensory modality. Finally, the posterior insula and S2 responded maximally during the sustained phase of non-nociceptive stimulation but not nociceptive stimulation, suggesting that these regions are preferentially involved in processing non-nociceptive somatosensory input. Hum Brain Mapp 36:4346-4360, 2015. (c) 2015 Wiley Periodicals, Inc.; National Natural Science Foundation of China [31200856, 31471082]; Mandat d'Impulsion Scientifique of the Belgian FNRS [14613969]; ERC Starting Grant [PROBING-PAIN: 336130]; SCI(E); PubMed; ARTICLE; huli@swu.edu.cn; lihongszu@szu.edu.cn; 11; 4346-4360; 36
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418488]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Hu, Li,Zhang, Li,Chen, Rui,et al. The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs[J]. HUMAN BRAIN MAPPING,2015.
APA	Hu, Li,Zhang, Li,Chen, Rui,Yu, Hongbo,Li, Hong,&Mouraux, Andre.(2015).The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs.HUMAN BRAIN MAPPING.
MLA	Hu, Li,et al."The primary somatosensory cortex and the insula contribute differently to the processing of transient and sustained nociceptive and non-nociceptive somatosensory inputs".HUMAN BRAIN MAPPING (2015).