Interactive effects of morphine and scopolamine, MK-801, propanolol on   spatial working memory in rhesus monkeys

doi:10.1016/j.neulet.2012.06.056

CORC > 北京大学 > 心理与认知科学学院

	Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys
	Wang, JianHong ; Chen, YanMei ; Carlson, Synnove ; Li, Liang ; Hu, XinTian ; Ma, YuanYe
刊名	神经科学快报
	2012
关键词	Working memory Morphine Scopolamine MK-801 Propranolol Rhesus monkeys PREFRONTAL CORTEX RECOGNITION MEMORY OPIOID RECEPTOR MOTOR CONTROL MICE MODULATION MAZE NORADRENALINE CONSOLIDATION ACETYLCHOLINE
DOI	10.1016/j.neulet.2012.06.056
英文摘要	Opiate, cholinergic, glutamatergic and beta-adrenergic neurotransmitters play key roles in learning and memory in humans and animals. Dysfunction of the interactions between these neurotransmitters may induce human diseases. In the present study, the interactions of morphine and acetylcholine (ACh). NMDA, and beta-adrenergic receptor antagonist (scopolamine, MK-801, and propanolol) were evaluated in a single-blind design by co-administrations of morphine and these drugs in a delayed response in rhesus monkeys. The results indicated that: (1) Co-administration of morphine and scopolamine deteriorated spatial working memory. (2) Co-treatment of morphine and MK-801 restored impairment caused by morphine and MK-801 in a dose-depending pattern. (3) Morphine plus propranolol impaired spatial working memory. High dose of morphine (0.01 mg/kg) reversed impaired spatial working memory induced by single propranolol and morphine treatment. These data suggested that the interactions of morphine and AChergic, NMDAergic and beta-adrenergic compounds were involved in spatial working memory in rhesus monkeys. (C) 2012 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); 2; ARTICLE; 2; 119-124; 523
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/231720]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Wang, JianHong,Chen, YanMei,Carlson, Synnove,et al. Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys[J]. 神经科学快报,2012.
APA	Wang, JianHong,Chen, YanMei,Carlson, Synnove,Li, Liang,Hu, XinTian,&Ma, YuanYe.(2012).Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys.神经科学快报.
MLA	Wang, JianHong,et al."Interactive effects of morphine and scopolamine, MK-801, propanolol on spatial working memory in rhesus monkeys".神经科学快报 (2012).