Dysregulated daily rhythmicity of neuronal resting-state networks in MCI   patients

doi:10.3109/07420528.2014.944618

CORC > 北京大学 > 心理与认知科学学院

	Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients
	Blautzik, Janusch ; Vetter, Celine ; Schneider, Annalisa ; Gutyrchik, Evgeny ; Reinisch, Veronika ; Keeser, Daniel ; Paolini, Marco ; Poeppel, Ernst ; Bao, Yan ; Reiser, Maximilian ; Roenneberg, Till ; Meindl, Thomas
刊名	国际时间生物学
	2014
关键词	Daily rhythmicity fMRI healthy aging MCI resting-state networks MILD COGNITIVE IMPAIRMENT ALZHEIMERS-DISEASE DEFAULT-MODE HUMAN BRAIN FUNCTIONAL CONNECTIVITY CIRCADIAN CLOCK FMRI CORTEX OPTIMIZATION REGISTRATION
DOI	10.3109/07420528.2014.944618
英文摘要	In young healthy participants, the degree of daily rhythmicity largely varies across different neuronal resting-state networks (RSNs), while it is to date unknown whether this temporal pattern of activity is conserved in healthy and pathological aging. Twelve healthy elderly (mean age = 65.1 +/- 5.7 years) and 12 patients with amnestic mild cognitive impairment (aMCI; mean age = 69.6 +/- 6.2 years) underwent four resting-state functional magnetic resonance imaging scans at fixed 2.5 h intervals throughout a day. Time courses of a RSN were extracted by a connectivity strength and a spatial extent approach performed individually for each participant. Highly rhythmic RSNs included a sensorimotor, a cerebellar and a visual network in healthy elderly; the least rhythmic RSNs in this group included a network associated with executive control and an orbitofrontal network. The degree of daily rhythmicity in aMCI patients was reduced and dysregulated. For healthy elderly, the findings are in accordance with results reported for young healthy participants suggesting a comparable distribution of daily rhythmicity across RSNs during healthy aging. In contrast, the reduction and dysregulation of daily rhythmicity observed in aMCI patients is presumably indicative of underlying neurodegenerative processes in this; Biology; Physiology; SCI(E); 0; ARTICLE; janusch.blautzik@med.uni-muenchen.de; 9; 1041-1050; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/207507]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Blautzik, Janusch,Vetter, Celine,Schneider, Annalisa,et al. Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients[J]. 国际时间生物学,2014.
APA	Blautzik, Janusch.,Vetter, Celine.,Schneider, Annalisa.,Gutyrchik, Evgeny.,Reinisch, Veronika.,...&Meindl, Thomas.(2014).Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients.国际时间生物学.
MLA	Blautzik, Janusch,et al."Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients".国际时间生物学 (2014).