Disruption of dopamine D1 receptor phosphorylation at serine 421   attenuates cocaine-induced behaviors in mice

doi:10.1007/s12264-014-1473-9

CORC > 北京大学 > 心理与认知科学学院

	Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice
	Zhang, Ying ; Wang, Ning ; Su, Ping ; Lu, Jie ; Wang, Yun
刊名	神经科学通报
	2014
关键词	protein kinase D1 dopamine D1 receptor phosphorylation cocaine addiction conditioned place preference locomotor activity AGONIST-INDUCED DESENSITIZATION CONDITIONED PLACE PREFERENCE D3 RECEPTORS REWARD HYPERACTIVITY ELIMINATION TRANSPORTER ACTIVATION ADDICTION
DOI	10.1007/s12264-014-1473-9
英文摘要	Dopamine D1 receptors (D1Rs) play a key role in cocaine addiction, and multiple protein kinases such as GRKs, PKA, and PKC are involved in their phosphorylation. Recently, we reported that protein kinase D1 phosphorylates the D1R at S421 and promotes its membrane localization. Moreover, this phosphorylation of S421 is required for cocaineinduced behaviors in rats. In the present study, we generated transgenic mice over-expressing S421A-D1R in the forebrain. These transgenic mice showed reduced phospho-D1R (S421) and its membrane localization, and reduced downstream ERK1/2 activation in the striatum. Importantly, acute and chronic cocaine-induced locomotor hyperactivity and conditioned place preference were significantly attenuated in these mice. These findings provide in vivo evidence for the critical role of S421 phosphorylation of the D1R in its membrane localization and in cocaine-induced behaviors. Thus, S421 on the D1R represents a potential pharmacotherapeutic target for cocaine addiction and other drug-abuse disorders.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345750500013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 1; ARTICLE; wangy66@bjmu.edu.cn; 6; 1025-1035; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188924]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Ying,Wang, Ning,Su, Ping,et al. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice[J]. 神经科学通报,2014.
APA	Zhang, Ying,Wang, Ning,Su, Ping,Lu, Jie,&Wang, Yun.(2014).Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.神经科学通报.
MLA	Zhang, Ying,et al."Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice".神经科学通报 (2014).