Effects of adolescent social isolation on the expression of   brain-derived neurotrophic factors in the forebrain

doi:10.1016/j.ejphar.2010.09.061

CORC > 北京大学 > 心理与认知科学学院

	Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain
	Meng, Qingxuan ; Li, Nanxin ; Han, Xiao ; Shao, Feng ; Wang, Weiwen
刊名	european journal of pharmacology
	2011
关键词	Adolescent BDNF Frontal cortex Hippocampus Social isolation ISOLATION-REARED RATS PREPULSE INHIBITION RECEPTOR ANTAGONIST NUCLEUS-ACCUMBENS GENE-EXPRESSION STRESS IMMUNOREACTIVITY HIPPOCAMPUS DISORDERS RESPONSES
DOI	10.1016/j.ejphar.2010.09.061
英文摘要	Adolescence is a critical period for the development of neural plasticity Social isolation is an important animal model for various neurodevelopmental disorders Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity and aberrations in its expression have been implicated in many brain disorders However to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals In the present study we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by lour-week standarad housing until adulthood for molecular assays BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry including frontal and cingulate cortex as well as hippocampus Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub fields of the hippocampus including CA I CA2/3 and dentate gyms This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders (C) 2010 Elsevier B V All rights reserved; Pharmacology & Pharmacy; SCI(E); PubMed; 9; ARTICLE; 1; 229-232; 650
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162837]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Meng, Qingxuan,Li, Nanxin,Han, Xiao,et al. Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain[J]. european journal of pharmacology,2011.
APA	Meng, Qingxuan,Li, Nanxin,Han, Xiao,Shao, Feng,&Wang, Weiwen.(2011).Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain.european journal of pharmacology.
MLA	Meng, Qingxuan,et al."Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain".european journal of pharmacology (2011).