Maternal separation induces alterations of serotonergic system in   different aged rats

doi:10.1016/j.brainresbull.2013.03.003

CORC > 北京大学 > 心理与认知科学学院

	Maternal separation induces alterations of serotonergic system in different aged rats
	Xue, Xiaofang ; Shao, Shuang ; Li, Man ; Shao, Feng ; Wang, Weiwen
刊名	脑研究通报
	2013
关键词	Maternal separation 5-HT Prefrontal cortex Nucleus accumbens Hippocampus CENTRAL-NERVOUS-SYSTEM EARLY-LIFE STRESS ADULT RATS PREPULSE INHIBITION LATENT INHIBITION BRAIN DEPRIVATION ADOLESCENT SCHIZOPHRENIA NEURODEVELOPMENT
DOI	10.1016/j.brainresbull.2013.03.003
英文摘要	Maternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus of juvenile (post-natal day 21, PND 21), adolescent (PND 35) and early adult (PND 56) male Wistar rats. We found that MS increased 5-HT levels in the PFC of juvenile rats, and although MS increased 5-HT and 5-HIAA levels in the NAc of adolescent rats, the ratio between 5-HIAA and 5-HT decreased in the PFC. In addition, MS-treated adult rats showed increased levels of 5-HT in the PFC as well as 5-HT and 5-HIAA in the NAc. These data provided evidence that MS leads to profound and age-specific changes in serotonergic synthesis and activity in rodents. Our study also found that there are U-shaped and inverted U-shaped patterns for serotonergic synthesis and serotonergic activity from younger rats to adults, respectively. Together, our findings support the use of maternal separation as an animal model for studying the neurobiological pathogenesis of neurodevelopmental diseases. (C) 2013 Elsevier Inc. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325741300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 9; ARTICLE; 15-20; 95
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162769]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Xue, Xiaofang,Shao, Shuang,Li, Man,et al. Maternal separation induces alterations of serotonergic system in different aged rats[J]. 脑研究通报,2013.
APA	Xue, Xiaofang,Shao, Shuang,Li, Man,Shao, Feng,&Wang, Weiwen.(2013).Maternal separation induces alterations of serotonergic system in different aged rats.脑研究通报.
MLA	Xue, Xiaofang,et al."Maternal separation induces alterations of serotonergic system in different aged rats".脑研究通报 (2013).