Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy   outcomes in mice

doi:10.1038/ncomms14585

CORC > 北京大学 > 城市与环境学院

	Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice
	Zhang, Zhaobin ; Hu, Ying ; Guo, Jilong ; Yu, Tong ; Sun, Libei ; Xiao, Xuan ; Zhu, Desheng ; Nakanishi, Tsuyoshi ; Hiromori, Youhei ; Li, Junyu ; Fan, Xiaolin ; Wan, Yi ; Cheng, Siyu ; Li, Jun ; Guo, Xuan ; Hu, Jianying
刊名	NATURE COMMUNICATIONS
	2017
关键词	TANDEM MASS-SPECTROMETRY BISPHENOL-A SUBSTITUTES YEAST 2-HYBRID ASSAY LARGE GENE LISTS MAMMARY-GLAND ENVIRONMENTAL EXPOSURES REPRODUCTIVE TOXICITY CHEMICALS RECEPTOR DIETARY
DOI	10.1038/ncomms14585
英文摘要	Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for the production of so-called 'BPA-free' plastics. Here we show that BHPF is released from commercial 'BPA-free' plastic bottles into drinking water and has anti-oestrogenic effects in mice. We demonstrate that BHPF has anti-oestrogenic activity in vitro and, in an uterotrophic assay in mice, induces low uterine weight, atrophic endometria and causes adverse pregnancy outcomes, even at doses lower than those of BPA for which no observed adverse effect have been reported. Female mice given water containing BHPF released from plastic bottles, have detectable levels of BHPF in serum, low uterine weights and show decreased expressions of oestrogen-responsive genes. We also detect BHPF in the plasma of 7/100 individuals, who regularly drink water from plastic bottles. Our data suggest that BPA substitutes should be tested for anti-oestrogenic activity and call for further study of the toxicological effects of BHPF on human health.; National Natural Science Foundation of China [21377007, 41330637]; International S&T Cooperation Program of China [2016YFE0117800]; 111 project [B14001]; SCI(E); ARTICLE; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474980]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Zhang, Zhaobin,Hu, Ying,Guo, Jilong,et al. Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice[J]. NATURE COMMUNICATIONS,2017.
APA	Zhang, Zhaobin.,Hu, Ying.,Guo, Jilong.,Yu, Tong.,Sun, Libei.,...&Hu, Jianying.(2017).Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice.NATURE COMMUNICATIONS.
MLA	Zhang, Zhaobin,et al."Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice".NATURE COMMUNICATIONS (2017).