Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation   of N-nitrosodimethylamine in rat: Implication on carcinogenic risk

doi:10.1016/j.chemosphere.2015.06.077

CORC > 北京大学 > 城市与环境学院

	Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk
	Ma, Fujun ; Zhang, Zhaobin ; Jiang, Jialiong ; Hu, Jianying
刊名	CHEMOSPHERE
	2015
关键词	Cr(VI) Nitrosamines DNA adduct CYP 2E1 enzyme activity GSH NITROSO COMPOUNDS OXIDATIVE STRESS 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE HEPATOCARCINOGENESIS NITROSODIETHYLAMINE NITROSAMINES ANTIOXIDANTS EXPOSURE ENZYMES METALS
DOI	10.1016/j.chemosphere.2015.06.077
英文摘要	Chromium (VI) [Cr(VI)] and nitrosamines such as N-nitrosodimethylamine (NDMA) exist commonly in the environment. To evaluate the potential influence of Cr(VI) co-exposure on the carcinogenic risk of NDMA, Female Wistar rats were treated with various concentrations of Cr(VI) and/or NDMA via drinking water for 15 days and the DNA adducts (O-6-methylguanine, O-6-MeG) of NDMA in liver tissue was used as a bioindicator. The results showed that Cr(VI) synergistically enhanced the O-6-MeG formation, which could lead to an increase in DNA damage and carcinogenic potential. Although Cr(VI) did not alter the CYP 2E1 enzyme activity, it decreased GSH content, which would be an potential mechanism for the potentiated O-6-MeG formation by Cr(VI) co-exposure. These results would contribute to the development of quantitative risk assessment of NDMA or even for a group of nitrosamines under environmental mixture exposure. (C) 2015 Elsevier Ltd. All rights reserved.; National Natural Science Foundation of China [41330637]; National Special Funding Project for Water Pollution Control and Management of China [2014ZX07405001]; SCI(E); EI; PubMed; ARTICLE; hujy@urban.pku.edu.cn; 256-259; 139
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415478]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Ma, Fujun,Zhang, Zhaobin,Jiang, Jialiong,et al. Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk[J]. CHEMOSPHERE,2015.
APA	Ma, Fujun,Zhang, Zhaobin,Jiang, Jialiong,&Hu, Jianying.(2015).Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk.CHEMOSPHERE.
MLA	Ma, Fujun,et al."Chromium (VI) potentiates the DNA adducts (O-6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk".CHEMOSPHERE (2015).