Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or   Man-Made Flame Retardants?

doi:10.1021/es901357u

CORC > 北京大学 > 城市与环境学院

	Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?
	Wan, Yi ; Wiseman, Steve ; Chang, Hong ; Zhang, Xiaowei ; Jones, Paul D. ; Hecker, Markus ; Kannan, Kurunthachalam ; Tanabe, Shinsuke ; Hu, Jianying ; Lam, Michael H. W. ; Giesy, John P.
刊名	environmental science technology
	2009
关键词	MARINE FOOD-WEB IN-VITRO POLYCHLORINATED-BIPHENYLS CATALYTIC-ACTIVITY PBDE METABOLITES EXPOSED RATS POLAR BEARS BALTIC SEA IDENTIFICATION CELLS
DOI	10.1021/es901357u
英文摘要	Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants. The structurally related hydroxylated PBDEs (OH-PBDEs) and methoxylated PBDEs (MeO-PBDEs) occur in precipitation, surface water, wildlife, and humans. The formation of OH-PBDEs in wildlife and humans is of considerable concern due to their greater toxicities relative to PBDEs and MeO-PBDEs. Research to date suggests that OH-PBDEs are formed by hydroxylation of PBDEs, and MeO-PBDEs are then formed by methylation of the OH-PBDEs. Here we show significant metabolic production of OH-PBDEs from MeO-PBDEs while hydroxylation of synthetic PBDEs to OH-PBDEs was negligible. Concentrations of PBDEs, OH-PBDEs, and MeO-PBDEs were analyzed in tuna, albatross, and polar bears collected from marine environments worldwide, and we found a closer relationship between OH-PBDEs and MeO-PBDEs than had been previously reported. Furthermore, for the first time the metabolic relationships between PBDEs, OH-PBDEs, and MeO-PBDEs were elucidated in vitro using rainbow trout chicken, and rat microsomes. We propose the production of OH-PBDEs from naturally occurring MeO-PBDEs as a previously unidentified mechanism that could be an important contributor for the occurrence of OH-PBDEs found in wildlife from remote areas. Our results suggest that risk assessment paradigms for PBDEs and their metabolites need reevaluation and that human exposure to MeO-PBDEs that occur naturally in marine organisms should be considered.; Engineering, Environmental; Environmental Sciences; SCI(E); EI; 109; ARTICLE; 19; 7536-7542; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/246162]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Wan, Yi,Wiseman, Steve,Chang, Hong,et al. Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?[J]. environmental science technology,2009.
APA	Wan, Yi.,Wiseman, Steve.,Chang, Hong.,Zhang, Xiaowei.,Jones, Paul D..,...&Giesy, John P..(2009).Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?.environmental science technology.
MLA	Wan, Yi,et al."Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?".environmental science technology (2009).