The Function of the DegP (HtrA) Protein: Protease Versus Chaperone

doi:10.1002/iub.1561

CORC > 北京大学 > 生命科学学院

	The Function of the DegP (HtrA) Protein: Protease Versus Chaperone
	Chang, Zengyi
刊名	IUBMB LIFE
	2016
关键词	periplasmic space protein quality control outer membrane protein biogenesis OUTER-MEMBRANE PROTEINS HEAT-SHOCK-PROTEIN ESCHERICHIA-COLI PERIPLASMIC PROTEINS MOLECULAR CHAPERONES GENE BIOGENESIS IDENTIFICATION TEMPERATURES DEGRADATION
DOI	10.1002/iub.1561
英文摘要	The DegP (or HtrA) is a highly conserved family of proteins functioning in all living organisms. It was initially identified as a protease functioning in the periplasmic space of the Gram-negative bacterial cells. It was later reported to also exhibit chaperone activity and thus has been designated as a bifunctional protein. However, recent studies demonstrated that in living cells it more likely functions only as a protease with hardly detectable chaperone activities. In this review, I will summarize the evidences clarifying that DegP more likely only functions as a protease rather than as a chaperone in cells. (C) 2016 IUBMB Life; National Basic Research Program of China (973 Program) [2012CB917300]; National Natural Science Foundation of China [31170738, 31470766]; SCI(E); PubMed; REVIEW; changzy@pku.edu.cn; 11,SI; 904-907; 68
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/492778]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chang, Zengyi. The Function of the DegP (HtrA) Protein: Protease Versus Chaperone[J]. IUBMB LIFE,2016.
APA	Chang, Zengyi.(2016).The Function of the DegP (HtrA) Protein: Protease Versus Chaperone.IUBMB LIFE.
MLA	Chang, Zengyi."The Function of the DegP (HtrA) Protein: Protease Versus Chaperone".IUBMB LIFE (2016).