A gene browser of colorectal cancer with literature evidence and   pre-computed regulatory information to identify key tumor suppressors   and oncogenes

doi:10.1038/srep30624

CORC > 北京大学 > 生命科学学院

	A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes
	Zhao, Min ; Liu, Yining ; Huang, Fuda ; Qu, Hong
刊名	SCIENTIFIC REPORTS
	2016
关键词	ACID RECEPTORS WEB RESOURCE EXPRESSION PROFILES DATABASE POLYMORPHISMS ASSOCIATION BIOMARKER PATTERNS GENOMES
DOI	10.1038/srep30624
英文摘要	Colorectal cancer (CRC) is a cancer of growing incidence that associates with a high mortality rate worldwide. There is a poor understanding of the heterogeneity of CRC with regard to causative genetic mutations and gene regulatory mechanisms. Previous studies have identified several susceptibility genes in small-scale experiments. However, the information has not been comprehensively and systematically compiled and interpreted. In this study, we constructed the gbCRC, the first literature-based gene resource for investigating CRC-related human genes. The features of our database include: (i) manual curation of experimentally-verified genes reported in the literature; (ii) comprehensive integration of five reliable data sources; and (iii) pre-computed regulatory patterns involving transcription factors, microRNAs and long non-coding RNAs. In total, 2067 genes associating with 2819 PubMed abstracts were compiled. Comprehensive functional annotations associated with all the genes, including gene expression profiles, homologous genes in other model species, protein-protein interactions, somatic mutations, and potential methylation sites. These comprehensive annotations and this pre-computed regulatory information highlighted the importance of the gbCRC with regard to the unexplored regulatory network of CRC. This information is available in a plain text format that is free to download.; National Natural Science Foundation of China [31171270]; University of the Sunshine Coast; SCI(E); PubMed; ARTICLE; mzhao@usc.edu.au; quh@mail.cbi.pku.edu.cn; 30624; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/491806]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, Min,Liu, Yining,Huang, Fuda,et al. A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes[J]. SCIENTIFIC REPORTS,2016.
APA	Zhao, Min,Liu, Yining,Huang, Fuda,&Qu, Hong.(2016).A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes.SCIENTIFIC REPORTS.
MLA	Zhao, Min,et al."A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes".SCIENTIFIC REPORTS (2016).