尿甲醛在阿尔茨海默病诊断中的价值及影响因素

doi:10.3760/cma.j.issn.1674-6554.2017.07.009

CORC > 北京大学 > 生命科学学院

	尿甲醛在阿尔茨海默病诊断中的价值及影响因素; Diagnostic value of urine formaldehyde in Alzheimer's disease and its influential factors
	吕继辉 ; 赫荣乔 ; 李文杰 ; 马毅 ; 魏翠柏 ; 秦伟 ; 张研 ; 苏涛
刊名	中华行为医学与脑科学杂志
	2017
关键词	阿尔茨海默病尿甲醛 ApoEε4基因 Alzheimer& s disease Urine formaldehyde ApoE ε4 gene #39
DOI	10.3760/cma.j.issn.1674-6554.2017.07.009
英文摘要	目的评估尿甲醛水平检测在阿尔茨海默病(AD)诊断中的价值及AD患者尿甲醛水平的影响因素.方法用队列研究的方法纳入AD患者52名,认知正常者53名.受试者均≥65岁,排除急性感染、心肝肾等重要脏器功能不全.比较两组受试者晨起空腹尿液甲醛水平;多元回归的方法分析AD患者尿液甲醛水平与年龄、性别、发病年龄、认知水平(MMSE评分)、精神症状(NPI评分)、海马萎缩程度(MTA分级)及ApoE ε4基因的关系.结果 AD患者尿甲醛水平高于认知正常者[AD患者:(13.27±4.16)μmol/L;认知正常者:(10.76±4.47)μmol/L,t=2.99,P=0.15].MMSE评分(β=-0.35,P=0.03),海马萎缩程度(β=-0.38,P=0.02)是尿甲醛水平的影响因素;性别、年龄、发病年龄、精神症状和是否携带ApoE ε4基因等对AD患者尿甲醛水平的影响无统计学意义(均P>0.05).结论尿液甲醛检测有望成为AD诊断标志物和病情严重程度的评价指标.; Objective To explore the value of urine formaldehyde test in the diagnosis of Alzheimer's disease (AD),and the influential factors of urine formaldehyde level in AD patients.Methods A total of 52 AD patients and 53 cognitively normal controls were recruited in a cohort study.All subjects were no less than 65 years old,and those with acute infection,or dysfunction in heart,liver or kidneys were excluded.The impact of age,gender,onset age,MMSE score,NPI score,MTA score,and ApoE ε4 gene on urine formaldehyde of AD patients were analyzed by multiple regression analysis.Results Urine formaldehyde level of AD group was statistically higher than that of cognitively normal control group ((13.27±4.16)μmol/L vs (10.76±4.47)μmol/L,t=2.99,P=0.15).Urine formaldehyde of AD patients was statistically negatively correlated with MMSE score (β=-0.35,P=0.03) and MTA score (β=-0.38,P=0.02).The impact of onset age,neuropsychiatric disorders and ApoE ε4 gene on urine formaldehyde of AD patients was not statistically significant(all P>0.05).Conclusion Urine formaldehyde level is worthwhile to be explored as a marker in AD diagnosis and severity assessment.; 北京市科学技术委员会首都临床特色应用研究专项(Z151100004015023)Beijing Municipal Science and Technology Commission,Capital Clinical Special Application Research Project; 中国科学引文数据库(CSCD); 7; 620-623; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/476725]
专题	生命科学学院
推荐引用方式 GB/T 7714	吕继辉,赫荣乔,李文杰,等. 尿甲醛在阿尔茨海默病诊断中的价值及影响因素, Diagnostic value of urine formaldehyde in Alzheimer's disease and its influential factors[J]. 中华行为医学与脑科学杂志,2017.
APA	吕继辉.,赫荣乔.,李文杰.,马毅.,魏翠柏.,...&苏涛.(2017).尿甲醛在阿尔茨海默病诊断中的价值及影响因素.中华行为医学与脑科学杂志.
MLA	吕继辉,et al."尿甲醛在阿尔茨海默病诊断中的价值及影响因素".中华行为医学与脑科学杂志 (2017).