The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by   Targeting the TIE1 Transcriptional Repressor for Degradation

doi:10.1105/tpc.16.00771

CORC > 北京大学 > 生命科学学院

	The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting the TIE1 Transcriptional Repressor for Degradation
	Zhang, Jinzhe ; Wei, Baoye ; Yuan, Rongrong ; Wang, Jianhui ; Ding, Mingxin ; Chen, Zhuoyao ; Yu, Hao ; Qin, Genji
刊名	PLANT CELL
	2017
关键词	NEGATIVE REGULATOR UBIQUITIN-LIGASES ORGAN SIZE PROTEIN PLANTS GROWTH HOS1 EXPRESSION RESPONSES CONSTANS
DOI	10.1105/tpc.16.00771
英文摘要	The developmental plasticity of leaf size and shape is important for leaf function and plant survival. However, the mechanisms by which plants form diverse leaves in response to environmental conditions are not well understood. Here, we identified TIE1-ASSOCIATED RING-TYPE E3 LIGASE1 (TEAR1) and found that it regulates leaf development by promoting the degradation of TCP INTERACTOR-CONTAINING EAR MOTIF PROTEIN1 (TIE1), an important repressor of CINCINNATA (CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors, which are key for leaf development. TEAR1 contains a typical C3H2C3-type RING domain and has E3 ligase activity. We show that TEAR1 interacts with the TCP repressor TIE1, which is ubiquitinated in vivo and degraded by the 26S proteasome system. We demonstrate that TEAR1 is colocalized with TIE1 in nuclei and negatively regulates TIE1 protein levels. Overexpression of TEAR1 rescued leaf defects caused by TIE1 overexpression, whereas disruption of TEAR1 resulted in leaf phenotypes resembling those caused by TIE1 overexpression or TCP dysfunction. Deficiency in TEAR partially rescued the leaf defects of TCP4 overexpression line and enhanced the wavy leaf phenotypes of jaw-5D. We propose that TEAR1 positively regulates CIN-like TCP activity to promote leaf development by mediating the degradation of the TCP repressor TIE1.; National Natural Science Foundation of China [31570284]; National Transformation Science and Technology Program [2016ZX08009003-003]; National Key Basic Research Program of the People's Republic of China [973-2012CB944801]; SCI(E); ARTICLE; 2; 243-259; 29
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/475376]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Jinzhe,Wei, Baoye,Yuan, Rongrong,et al. The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting the TIE1 Transcriptional Repressor for Degradation[J]. PLANT CELL,2017.
APA	Zhang, Jinzhe.,Wei, Baoye.,Yuan, Rongrong.,Wang, Jianhui.,Ding, Mingxin.,...&Qin, Genji.(2017).The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting the TIE1 Transcriptional Repressor for Degradation.PLANT CELL.
MLA	Zhang, Jinzhe,et al."The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting the TIE1 Transcriptional Repressor for Degradation".PLANT CELL (2017).