Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to   Regulate Responses to DNA Virus Infection

doi:10.1016/j.immuni.2017.02.011

CORC > 北京大学 > 生命科学学院

	Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
	Wang, Yutao ; Ning, Xiaohan ; Gao, Pengfei ; Wu, Shuxian ; Sha, Mengyin ; Lv, Mengze ; Zhou, Xiang ; Gao, Juyi ; Fang, Run ; Meng, Guangxun ; Su, Xiaodong ; Jiang, Zhengfan
刊名	IMMUNITY
	2017
关键词	NF-KAPPA-B CYCLIC GMP-AMP PYROPTOTIC CELL-DEATH DOUBLE-STRANDED-RNA I INTERFERON RIG-I CYTOSOLIC DNA ADAPTER PROTEIN HOST-DEFENSE INNATE
DOI	10.1016/j.immuni.2017.02.011
英文摘要	Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immune response that can resolve the infection without causing host pathology. In examining the inflammatory response of Asc(-/-) and Casp1(-/-) macrophages, we found that deficiency in these molecules resulted in increased IFN production upon DNA virus infection, but not RNA virus challenge. Investigation of the underlying mechanism revealed that upon canonical and non-canonical inflammasome activation, caspase- 1 interacted with cyclic GMP-AMP (cGAMP) synthase (cGAS), cleaving it and dampening cGASSTING- mediated IFN production. Deficiency in inflammasome signaling enhanced host resistance to DNA virus in vitro and in vivo, and this regulatory role extended to other inflammatory caspases. Thus, inflammasome activation dampens cGAS-dependent signaling, suggesting cross-regulation between intracellular DNA-sensing pathways.; Chinese Ministry of Science and Technology [2014CB542600, 2015CC040097]; China Natural Science Foundation [31230023, 91129000, 81621001]; SCI(E); ARTICLE; 3; 393-404; 46
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474529]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, Yutao,Ning, Xiaohan,Gao, Pengfei,et al. Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection[J]. IMMUNITY,2017.
APA	Wang, Yutao.,Ning, Xiaohan.,Gao, Pengfei.,Wu, Shuxian.,Sha, Mengyin.,...&Jiang, Zhengfan.(2017).Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.IMMUNITY.
MLA	Wang, Yutao,et al."Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection".IMMUNITY (2017).