MicroRNA-17-92 Regulates the Transcription Factor E2F3b during   Myogenesis In Vitro and In Vivo

doi:10.3390/ijms18040727

CORC > 北京大学 > 生命科学学院

	MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo
	Tang, Zhixiong ; Liu, Nian ; Luo, Lan ; Kang, Kang ; Li, Li ; Ni, Ruiyang ; Qiu, Huiling ; Gou, Deming
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2017
关键词	miR-20a E2F3b muscle SATELLITE CELLS DIFFERENTIATION IDENTIFICATION EXPRESSION MECHANISM
DOI	10.3390/ijms18040727
英文摘要	Myogenic differentiation, which occurs during muscle development, is a highly ordered process that can be regulated by E2F transcription factors. Available data show that E2F3b, but not E2F3a, is upregulated and required for myogenic differentiation. However, the regulation of E2F3b expression in myogenic differentiation is not well understood. To investigate whether E2Fb expression is controlled by miRNAs, we used bioinformatics to combine the database of microRNAs downregulated during myogenesis and those predicted to target E2F3. This identified miR-17 and miR-20a as miRNAs potentially involved in E2F3 regulation. We found that miR-17-92 controls the expression of E2F3b in C2C12 cells during myogenic differentiation. Moreover, we confirmed that miR-20a regulates the expression of E2F3b proteins in vivo using a muscle regeneration model.; National Basic Research Program of China (973 Program) [2012CB124701]; National Natural Science Foundation of China [81370151, 81570046, 31571199]; Shenzhen Municipal Basic Research Program [JCYJ20150729104027220, JCYJ20160520174217859]; Shenzhen Overseas High-Level Talents Innovation Program [YFZZ20111009]; Shenzhen High-tech Development Project [CXZZ20140828163951592]; Shenzhen University Interdisciplinary Innovation Team Project [000003]; Transgenic Project from the Ministry of Agriculture [2014ZX08009-051B]; SCI(E); ARTICLE; 4; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474155]
专题	生命科学学院
推荐引用方式 GB/T 7714	Tang, Zhixiong,Liu, Nian,Luo, Lan,et al. MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017.
APA	Tang, Zhixiong.,Liu, Nian.,Luo, Lan.,Kang, Kang.,Li, Li.,...&Gou, Deming.(2017).MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
MLA	Tang, Zhixiong,et al."MicroRNA-17-92 Regulates the Transcription Factor E2F3b during Myogenesis In Vitro and In Vivo".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017).