Caspases control antiviral innate immunity

doi:10.1038/cmi.2017.44

CORC > 北京大学 > 生命科学学院

	Caspases control antiviral innate immunity
	Chen, Huihui ; Ning, Xiaohan ; Jiang, Zhengfan
刊名	CELLULAR & MOLECULAR IMMUNOLOGY
	2017
关键词	apoptosis caspases I-IFNs inflammasome innate immunity NONCANONICAL INFLAMMASOME ACTIVATION DOUBLE-STRANDED-RNA PROGRAMMED CELL-DEATH NF-KAPPA-B INTERFERON REGULATORY FACTOR-3 PATTERN-RECOGNITION RECEPTORS ENDOPLASMIC-RETICULUM STRESS TOLL-LIKE RECEPTORS INFLUENZA-A-VIRUS INDUCIBLE GENE-I
DOI	10.1038/cmi.2017.44
英文摘要	Caspases are a family of cysteine proteases whose functions have been scrutinized intensively in recent years. Beyond their established roles in programmed cell death and inflammatory response, some caspases are also fundamental players in antiviral immunity by fine-tuning the levels of antiviral signaling adapters and cytokines, such as type. interferons, which serves as a major, sophisticated weapon against viruses. Viral infections can result in inflammasome activation and the initiation of cell death, including apoptosis and pyroptosis, and multiple caspases are significantly involved in these processes. This review will focus on the cutting-edge discoveries regarding the multifaceted roles of caspases in antiviral innate immunity.; Chinese Ministry of Science and Technology [2014CB542600, 2015CC040097]; China Natural Science Foundation [31230023, 91129000, 81621001]; SCI(E); REVIEW; 9; 736-747; 14
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/471149]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, Huihui,Ning, Xiaohan,Jiang, Zhengfan. Caspases control antiviral innate immunity[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2017.
APA	Chen, Huihui,Ning, Xiaohan,&Jiang, Zhengfan.(2017).Caspases control antiviral innate immunity.CELLULAR & MOLECULAR IMMUNOLOGY.
MLA	Chen, Huihui,et al."Caspases control antiviral innate immunity".CELLULAR & MOLECULAR IMMUNOLOGY (2017).