Altered Brain Network Connectivity as a Potential Endophenotype of   Schizophrenia

doi:10.1038/s41598-017-05774-3

CORC > 北京大学 > 生命科学学院

	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
	Li, Peng ; Fan, Teng-Teng ; Zhao, Rong-Jiang ; Han, Ying ; Shi, Le ; Sun, Hong-Qiang ; Chen, Si-Jing ; Shi, Jie ; Lin, Xiao ; Lu, Lin
刊名	SCIENTIFIC REPORTS
	2017
关键词	AUDITORY VERBAL HALLUCINATIONS FUNCTIONAL CONNECTIVITY RISK DISORDERS PSYCHOSIS RELATIVES
DOI	10.1038/s41598-017-05774-3
英文摘要	Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives. The correlation between functional connectivity with neurocognitive performance and clinical symptoms were calculated. Abnormalities of betweennetwork connectivity largely overlapped in patients and first-degree relatives, but the extent of such abnormalities was relatively minor in relatives. Negative connectivity between language networks and executive control networks was impaired in schizophrenia patients and their first-degree relatives, and this decreased connectivity was correlated with performance in language processing. Similar impairments were found in high-visual network and executive network coupling, and this decreased connection was correlated with the severity of positive symptoms in patients. The results indicated that abnormal functional connectivity within and between perceptual systems (i e., high-visual and language) and executive control networks was related to the generic risk of schizophrenia, which makes it a potential endophenotype for schizophrenia.; National Basic Research Program of China [2015CB856400]; National Natural Science Foundation of China [81501158, 81521063, 91432303, 31230033]; SCI(E); SSCI; ARTICLE; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469076]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Li, Peng,Fan, Teng-Teng,Zhao, Rong-Jiang,et al. Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia[J]. SCIENTIFIC REPORTS,2017.
APA	Li, Peng.,Fan, Teng-Teng.,Zhao, Rong-Jiang.,Han, Ying.,Shi, Le.,...&Lu, Lin.(2017).Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia.SCIENTIFIC REPORTS.
MLA	Li, Peng,et al."Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia".SCIENTIFIC REPORTS (2017).