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	Altered expression of mRNA profiles in blood of early-onset schizophrenia
	Yong Xu ; Dai Zhang ; Yin Yao Shugart ; Guoqiang Wang ; Chunhui Jin ; Kai Zhang ; Jun Wang ; Hao Yu ; Fuquan Zhang ; Weihua Yue
	2015
关键词	schizophrenia mRNA coexpression microarray
英文摘要	To identify gene expression abnormalities in schizophrenia (SZ) ,we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls.We detected 84 transcripts differentially expressed by affection status,with 82 genes being upregulated and 2 downregulated.We identified two gene coexpression modules (green and red) associated with SZ,including 446 genes altogether.The green module is positively correlated with SZ, encompassing predominantly over-expressed genes in SZ;while the red module was negatively correlated with disease status, involving mostly nominally under-expressed genes in SZ.CCDC 134, UBD, C 10orf67, ABIN-3, and ZIC2 are hub genes in the coexpression modules, while protein-protein interaction analysis suggests AKT1 ,CHEK1 and BRCA1 as hub genes.Our findings indicate that mRNA coexpression abnormalities may serve as a promising mechanism underlying the development of SZ.; 34-38
语种	英语
出处	中华医学会第十七次全国行为医学学术会议
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/451209]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yong Xu,Dai Zhang,Yin Yao Shugart,et al. Altered expression of mRNA profiles in blood of early-onset schizophrenia. 2015-01-01.

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