Accelerated progression of Hodgkin&apos;s-like lymphomas in golli deficient   SJL mice

doi:10.1016/j.cellimm.2016.01.006

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	Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice
	Ouyang, Suidong ; Han, Guangming ; Wu, Xiaochu ; Jiang, Zhengfan ; Feng, Ji-Ming
刊名	CELLULAR IMMUNOLOGY
	2016
关键词	Golli protein Regulatory T cell Foxp3 Hodgkin&apos REGULATORY T-CELLS IMMUNOLOGICAL SELF-TOLERANCE REVERSE IMMUNE SURVEILLANCE ACTIVATES CRAC CHANNELS STIM1 ORAI1 STORE INTERLEUKIN-10 EXPRESSION GENE s-like lymphoma
DOI	10.1016/j.cellimm.2016.01.006
英文摘要	Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated progression of Hodgkin's-like lymphoma which is accompanied by a facilitated conversion of FoxP3(+) Treg cells. Our results suggest that golli protein might affect the progression of Hodgkin's-like lymphomas through regulating the induction of Treg cells. (C) 2016 Elsevier Inc. All rights reserved.; National Multiple Sclerosis Society [RG3855A2/T]; intramural CORP fund by the School of Veterinary Medicine at LSU; SCI(E); PubMed; ARTICLE; jfeng@lsu.edu; 41-49; 302
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434935]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ouyang, Suidong,Han, Guangming,Wu, Xiaochu,et al. Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice[J]. CELLULAR IMMUNOLOGY,2016.
APA	Ouyang, Suidong,Han, Guangming,Wu, Xiaochu,Jiang, Zhengfan,&Feng, Ji-Ming.(2016).Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.CELLULAR IMMUNOLOGY.
MLA	Ouyang, Suidong,et al."Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice".CELLULAR IMMUNOLOGY (2016).