Tracking the Correlation Between CpG Island Methylator Phenotype and   Other Molecular Features and Clinicopathological Features in Human   Colorectal Cancers: A Systematic Review and Meta-Analysis

doi:10.1038/ctg.2016.14

CORC > 北京大学 > 生命科学学院

	Tracking the Correlation Between CpG Island Methylator Phenotype and Other Molecular Features and Clinicopathological Features in Human Colorectal Cancers: A Systematic Review and Meta-Analysis
	Zong, Liang ; Abe, Masanobu ; Ji, Jiafu ; Zhu, Wei-Guo ; Yu, Duonan
刊名	CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
	2016
关键词	DNA METHYLATION MICROSATELLITE INSTABILITY ADVERSE PROGNOSIS MUTATION CARCINOMA CHEMOTHERAPY EPIGENOTYPES ASSOCIATION SURVIVAL RISK
DOI	10.1038/ctg.2016.14
英文摘要	OBJECTIVES: The controversy of CpG island methylator phenotype (CIMP) in colorectal cancers (CRCs) persists, despite many studies that have been conducted on its correlation with molecular and clinicopathological features. To drive a more precise estimate of the strength of this postulated relationship, a meta-analysis was performed. METHODS: A comprehensive search for studies reporting molecular and clinicopathological features of CRCs stratified by CIMP was performed within the PubMed, EMBASE, and Cochrane Library. CIMP was defined by either one of the three panels of gene-specific CIMP markers (Weisenberger panel, classic panel, or a mixture panel of the previous two) or the genome-wide DNA methylation profile. The associations of CIMP with outcome parameters were estimated using odds ratio (OR) or weighted mean difference (WMD) or hazard ratios (HRs) with 95% confidence interval (CI) for each study using a fixed effects or random effects model. RESULTS: A total of 29 studies involving 9,393 CRC patients were included for analysis. We observed more BRAF mutations (OR 34.87; 95% CI, 22.49-54.06) and microsatellite instability (MSI) (OR 12.85 95% CI, 8.84-18.68) in CIMP-positive vs. -negative CRCs, whereas KRAS mutations were less frequent (OR 0.47; 95% CI, 0.30-0.75). Subgroup analysis showed that only the genome-wide methylation profile-defined CIMP subset encompassed all BRAF-mutated CRCs. As expected, CIMP-positive CRCs displayed significant associations with female (OR 0.64; 95% CI, 0.56-0.72), older age at diagnosis (WMD 2.77; 95% CI, 1.15-4.38), proximal location (OR 6.91; 95% CI, 5.17-9.23), mucinous histology (OR 3.81; 95% CI, 2.93-4.95), and poor differentiation (OR 4.22; 95% CI, 2.52-7.08). Although CIMP did not show a correlation with tumor stage (OR 1.10; 95% CI, 0.82-1.46), it was associated with shorter overall survival (HR 1.73; 95% CI, 1.27-2.37). CONCLUSIONS: The meta-analysis highlights that CIMP-positive CRCs take their own molecular feature, especially overlapping with BRAF mutations, and clinicopathological features and worse prognosis from CIMP-negative CRCs, suggesting CIMP could be used as an independent prognostic marker for CRCs.; National Natural Science Foundation of China [81470277]; Jiangsu Province Specially-appointed Professorship Start-up Fund; Ministry of Finance of China; Priority Academic Program Development of Jiangsu Higher Education Institution; SCI(E); PubMed; REVIEW; zhuweiguo@bjmu.edu.cn; yzuyu@sina.com; e151; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434550]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zong, Liang,Abe, Masanobu,Ji, Jiafu,et al. Tracking the Correlation Between CpG Island Methylator Phenotype and Other Molecular Features and Clinicopathological Features in Human Colorectal Cancers: A Systematic Review and Meta-Analysis[J]. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY,2016.
APA	Zong, Liang,Abe, Masanobu,Ji, Jiafu,Zhu, Wei-Guo,&Yu, Duonan.(2016).Tracking the Correlation Between CpG Island Methylator Phenotype and Other Molecular Features and Clinicopathological Features in Human Colorectal Cancers: A Systematic Review and Meta-Analysis.CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY.
MLA	Zong, Liang,et al."Tracking the Correlation Between CpG Island Methylator Phenotype and Other Molecular Features and Clinicopathological Features in Human Colorectal Cancers: A Systematic Review and Meta-Analysis".CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2016).