Tousled-like kinase mediated a new type of cell death pathway in   Drosophila

doi:10.1038/cdd.2015.77

CORC > 北京大学 > 生命科学学院

	Tousled-like kinase mediated a new type of cell death pathway in Drosophila
	Zhang, Y. ; Cai, R. ; Zhou, R. ; Li, Y. ; Liu, L.
刊名	CELL DEATH AND DIFFERENTIATION
	2016
关键词	JNK-DEPENDENT APOPTOSIS NEURONAL NECROSIS TNF SUPERFAMILY FLY EYE GENE RETINA MECHANISMS INFORMATION EXPRESSION AUTOPHAGY
DOI	10.1038/cdd.2015.77
英文摘要	Programmed cell death (PCD) has an important role in sculpting organisms during development. However, much remains to be learned about the molecular mechanism of PCD. We found that ectopic expression of tousled-like kinase (tlk) in Drosophila initiated a new type of cell death. Furthermore, the TLK-induced cell death is likely to be independent of the canonical caspase pathway and other known caspase-independent pathways. Genetically, atg2 RNAi could rescue the TLK-induced cell death, and this function of atg2 was likely distinct from its role in autophagy. In the developing retina, loss of tlk resulted in reduced PCD in the interommatidial cells (IOCs). Similarly, an increased number of IOCs was present in the atg2 deletion mutant clones. However, double knockdown of tlk and atg2 by RNAi did not have a synergistic effect. These results suggested that ATG2 may function downstream of TLK. In addition to a role in development, tlk and atg2 RNAi could rescue calcium overload-induced cell death. Together, our results suggest that TLK mediates a new type of cell death pathway that occurs in both development and calcium cytotoxicity.; Chinese Ministry of Science and Technology [2013CB530700]; National Natural Science Foundation of China [NSFC31171324]; SCI(E); PubMed; ARTICLE; yuhongli@pku.edu.cn; leiliu@ccmu.edu.cn; 1; 146-157; 23
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419241]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Y.,Cai, R.,Zhou, R.,et al. Tousled-like kinase mediated a new type of cell death pathway in Drosophila[J]. CELL DEATH AND DIFFERENTIATION,2016.
APA	Zhang, Y.,Cai, R.,Zhou, R.,Li, Y.,&Liu, L..(2016).Tousled-like kinase mediated a new type of cell death pathway in Drosophila.CELL DEATH AND DIFFERENTIATION.
MLA	Zhang, Y.,et al."Tousled-like kinase mediated a new type of cell death pathway in Drosophila".CELL DEATH AND DIFFERENTIATION (2016).