Uroplakin IIIb, a urothelial differentiation marker, dimerizes with   uroplakin Ib as an early step of urothelial plaque assembly

doi:10.1083/jcb.200204102

CORC > 北京大学 > 生命科学学院

	Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly
	Deng, FM ; Liang, FX ; Tu, LY ; Resing, KA ; Hu, P ; Supino, M ; Hu, CCA ; Zhou, G ; Ding, MX ; Kreibich, G ; Sun, TT
刊名	journal of cell biology
	2002
关键词	bladder urothelium tetraspanin membrane DNA mismatch repair enzyme WILLIAMS-BEUREN-SYNDROME ASYMMETRIC UNIT MEMBRANE DNA MISMATCH REPAIR BLADDER DIVERTICULA 7Q11.23 DELETIONS URINARY-BLADDER PROTEINS GENE REGION CELLS
DOI	10.1083/jcb.200204102
英文摘要	Urothelial plaques consist of four major uroplakins (Ia, Ib, II, and III) that form two-dimensional crystals covering the apical surface of urothelium, and provide unique opportunities for studying membrane protein assembly. Here, we describe a novel 35-kD urothelial plaque-associated glycoprotein that is closely related to uroplakin III: they have a similar overall type I transmembrane topology; their amino acid sequences are 34% identical; they share an extracellular juxtamembrane stretch of 19 amino acids; their exit from the ER requires their forming a heterodimer with uroplakin Ib, but not with any other uroplakins; and UPIII-knockout leads to p35 up-regulation, possibly as a compensatory mechanism. Interestingly, p35 contains a stretch of 80 amino acid residues homologous to a hypothetical human DNA mismatch repair enzyme-related protein. Human p35 gene is mapped to chromosome 7q11.23 near the telomeric duplicated region of Williams-Beuren syndrome, a developmental disorder affecting multiple organs including the urinary tract. These results indicate that p35 (uroplakin IIIb) is a urothelial differentiation product structurally and functionally related to uroplakin 111, and that p35-UPlb interaction in the ER is an important early step in urothelial plaque assembly.; Cell Biology; SCI(E); 0; ARTICLE; 4; 685-694; 159
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/401110]
专题	生命科学学院
推荐引用方式 GB/T 7714	Deng, FM,Liang, FX,Tu, LY,et al. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly[J]. journal of cell biology,2002.
APA	Deng, FM.,Liang, FX.,Tu, LY.,Resing, KA.,Hu, P.,...&Sun, TT.(2002).Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly.journal of cell biology.
MLA	Deng, FM,et al."Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly".journal of cell biology (2002).