Structure of orotate phosphoribosyltransferase from the caries pathogen   Streptococcus mutans

doi:10.1107/S1744309110009243

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	Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
	Liu, Chao-Pei ; Xu, Rui ; Gao, Zeng-Qiang ; Xu, Jian-Hua ; Hou, Hai-Feng ; Li, Li-Qin ; She, Zhun ; Li, Lan-Fen ; Su, Xiao-Dong ; Liu, Peng ; Dong, Yu-Hui
刊名	acta crystallographica section f structural biology and crystallization communications
	2010
关键词	KINETIC MECHANISM MACROMOLECULAR STRUCTURES CRYSTAL-STRUCTURE NMR SYSTEM CRYSTALLOGRAPHY REFINEMENT SITE
DOI	10.1107/S1744309110009243
英文摘要	Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 angstrom resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000277217700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography; SCI(E); 4; ARTICLE; 498-502; 66
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/395936]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Chao-Pei,Xu, Rui,Gao, Zeng-Qiang,et al. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans[J]. acta crystallographica section f structural biology and crystallization communications,2010.
APA	Liu, Chao-Pei.,Xu, Rui.,Gao, Zeng-Qiang.,Xu, Jian-Hua.,Hou, Hai-Feng.,...&Dong, Yu-Hui.(2010).Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans.acta crystallographica section f structural biology and crystallization communications.
MLA	Liu, Chao-Pei,et al."Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans".acta crystallographica section f structural biology and crystallization communications (2010).