Structure of the putative dihydroorotate dehydrogenase from   Streptococcus mutans

doi:10.1107/S1744309110048414

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	Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
	Liu, Ying ; Gao, Zeng-Qiang ; Liu, Chao-Pei ; Xu, Jian-Hua ; Li, Lan-Fen ; Ji, Chao-Neng ; Su, Xiao-Dong ; Dong, Yu-Hui
刊名	acta crystallographica section f structural biology and crystallization communications
	2011
关键词	LACTOCOCCUS-LACTIS BINDING
DOI	10.1107/S1744309110048414
英文摘要	Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase ( DHOD) from S. mutans, is reported at 2.4 angstrom resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reductive lysine-methylation procedure was applied in order to improve the diffraction qualities of the crystals. Analysis of the S. mutans DHOD crystal structure shows that this enzyme is a class 1A DHOD and also suggests potential sites that could be exploited for the design of highly specific inhibitors using the structure-based chemotherapeutic design technique.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000287030600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography; SCI(E); 5; ARTICLE; 182-187; 67
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/395202]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Ying,Gao, Zeng-Qiang,Liu, Chao-Pei,et al. Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans[J]. acta crystallographica section f structural biology and crystallization communications,2011.
APA	Liu, Ying.,Gao, Zeng-Qiang.,Liu, Chao-Pei.,Xu, Jian-Hua.,Li, Lan-Fen.,...&Dong, Yu-Hui.(2011).Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.acta crystallographica section f structural biology and crystallization communications.
MLA	Liu, Ying,et al."Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans".acta crystallographica section f structural biology and crystallization communications (2011).