Molecular regulation of sexual preference revealed by genetic studies of   5-HT in the brains of male mice

doi:10.1038/nature09822

CORC > 北京大学 > 生命科学学院

	Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice
	Liu, Yan ; Jiang, Yun&apos ; Si, Yunxia ; Kim, Ji-Young ; Chen, Zhou-Feng ; Rao, Yi ; ai
刊名	nature
	2011
关键词	PARA CHLOROPHENYLALANINE COPULATORY BEHAVIOUR MALE RATS SEROTONIN LACKING INNATE TRP2 MEN
DOI	10.1038/nature09822
英文摘要	Although the question of to whom a male directs his mating attempts(1,2) is a critical one in social interactions, little is known about the molecular and cellular mechanisms controlling mammalian sexual preference. Here we report that the neurotransmitter 5-hydroxytryptamine (5-HT) is required for male sexual preference. Wild-type male mice preferred females over males, but males lacking central serotonergic neurons lost sexual preference although they were not generally defective in olfaction or in pheromone sensing. A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain. Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wildtype level, adult Tph2 knockout mice also preferred females over males. These results indicate that 5-HT and serotonergic neurons in the adult brain regulate mammalian sexual preference.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289199400044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); 48; ARTICLE; 7341; 95-U125; 472
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/394863]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Yan,Jiang, Yun&apos,Si, Yunxia,et al. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice[J]. nature,2011.
APA	Liu, Yan.,Jiang, Yun&apos.,Si, Yunxia.,Kim, Ji-Young.,Chen, Zhou-Feng.,...&ai.(2011).Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice.nature.
MLA	Liu, Yan,et al."Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice".nature (2011).