Avian haemoglobins and structural basis of high affinity for oxygen:   structure of bar-headed goose aquomet haemoglobin

doi:10.1107/S0907444901004243

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	Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin
	Liu, XZ ; Li, SL ; Jing, H ; Liang, YH ; Hua, ZQ ; Lu, GY
刊名	acta crystallographica section d biological crystallography
	2001
关键词	HIGH-ALTITUDE RESPIRATION MINOR HEMOGLOBIN-COMPONENTS BETA-CHAINS RESOLUTION ADAPTATION MECHANISM BINDING SYSTEM GEESE
DOI	10.1107/S0907444901004243
英文摘要	Haemoglobin from the bar-headed goose (Anser indicus) has higher oxygen affinity than that from its lowland relatives such as greylag goose (A. anser). The crystal structure of bar-headed goose aquomet haemoglobin was determined at 2.3 Angstrom resolution and compared with the structures of the goose oxy, human, horse and other avian haemoglobins and the sequences of other avian haemoglobins. Four amino-acid residues differ between greylag goose and bar-headed goose haemoglobins, among which Ala alpha 119 and Asp beta 125 in bar-headed goose haemoglobin reduces the contacts between the alpha (1) and beta (1) subunits compared with Pro and Glu, respectively, and therefore may increase the oxygen affinity by loosening the alpha (1)beta (1) interface. Compared with human oxy haemoglobin, the relative orientation of two alpha beta dimers in the bar-headed goose aquomet and oxy Hbs are rotated by about 4 degrees, indicating a unique quaternary structural difference from the typical R state. This new 'R-H' state is probably correlated with the higher oxygen affinity of bar-headed goose haemoglobin.; Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography; SCI(E); PubMed; 19; ARTICLE; Pt 6; 775-783; 57
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/347461]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, XZ,Li, SL,Jing, H,et al. Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin[J]. acta crystallographica section d biological crystallography,2001.
APA	Liu, XZ,Li, SL,Jing, H,Liang, YH,Hua, ZQ,&Lu, GY.(2001).Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin.acta crystallographica section d biological crystallography.
MLA	Liu, XZ,et al."Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin".acta crystallographica section d biological crystallography (2001).