A novel zinc finger protein interacts with receptor-interacting protein   (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa   B activation

doi:10.1074/jbc.M108675200

CORC > 北京大学 > 生命科学学院

	A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation
	Chen, DY ; Li, XY ; Zhai, ZH ; Shu, HB
刊名	journal of biological chemistry
	2002
关键词	SIGNALS CELL-DEATH TNF RECEPTOR KINASE COMPLEX CD95 FAS/APO-1 IKK-GAMMA APOPTOSIS FADD A20 DOMAIN ALPHA
DOI	10.1074/jbc.M108675200
英文摘要	Receptor-interacting protein (RIP) is a serine/threonine protein kinase that is critically involved in tumor necrosis factor receptor-1 (TNF-R1)-induced NF-kappaB activation. In a yeast two-hybrid screening for potential RIP-interacting proteins, we identified ZIN (zinc finger protein inhibiting NF-kappaB), a novel protein that specifically interacts with RIP. ZIN contains four RING-like zinc finger domains at the middle and a proline-rich domain at the C terminus. Overexpression of ZIN inhibits RIP-, IKKbeta-, TNF-, and IL1-induced NF-kappaB activation in a dose-dependent manner in 293 cells. Domain mapping experiments indicate that the RING-like zinc finger domains of ZIN are required for its interaction with RIP and inhibition of RIP-mediated NF-kappaB activation. Overexpression of ZIN also potentiates RIP- and TNF-induced apoptosis. Moreover, immunofluorescent staining indicates that ZIN is a cytoplasmic protein and that it colocalizes with RIP. Our findings suggest that ZIN is an inhibitor of TNF- and IL1-induced NF-kappaB activation pathways.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000175510400103&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; SCI(E); PubMed; 38; ARTICLE; 18; 15985-15991; 277
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/347384]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, DY,Li, XY,Zhai, ZH,et al. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation[J]. journal of biological chemistry,2002.
APA	Chen, DY,Li, XY,Zhai, ZH,&Shu, HB.(2002).A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.journal of biological chemistry.
MLA	Chen, DY,et al."A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation".journal of biological chemistry (2002).