Sequential action of Caenorhabditis elegans Rab GTPases regulates   phagolysosome formation during apoptotic cell degradation

doi:10.1073/pnas.1008946107

CORC > 北京大学 > 生命科学学院

	Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation
	Guo, Pengfei ; Hu, Tianjing ; Zhang, Juan ; Jiang, Shanya ; Wang, Xiaochen
刊名	proceedings of the national academy of sciences of the united states of america
	2010
关键词	PHAGOSOME MATURATION C-ELEGANS SPECIFICITY ENGULFMENT REMOVAL PATHWAY
DOI	10.1073/pnas.1008946107
英文摘要	Phagocytosis of apoptotic cells requires recognition of cell corpses followed by internalization and enclosure within plasma membrane-derived phagosomes. Phagosomes undergo maturation to generate phagolysosomes in which cell corpses are degraded; however, regulation of the maturation process is poorly understood. Here, we identified Rab GTPase 14, which regulates apoptotic cell degradation in Caenorhabditis elegans. rab-14 mutants accumulate many persistent cell corpses owing to defective cell corpse clearance. Loss of rab-14 function affects several steps of phagosome maturation including phagosomal acidification and phagolysosome formation. RAB-14 and UNC-108/RAB2 are recruited to phagosomes at a similar stage and function redundantly to regulate phagosome maturation. Three Rabs, RAB-14, UNC-108/RAB2, and RAB-7, act in sequential steps to control phagolysosome formation. RAB-14 and UNC-108 recruit lysosomes, whereas RAB-7 mediates fusion of lysosomes to phagosomes. Our data reveal the sequential action of Rab GTPases in regulating tethering, docking, and fusion of lysosomes to apoptotic cell-containing phagosomes.; Multidisciplinary Sciences; SCI(E); PubMed; 21; ARTICLE; 42; 18016-18021; 107
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/344687]
专题	生命科学学院
推荐引用方式 GB/T 7714	Guo, Pengfei,Hu, Tianjing,Zhang, Juan,et al. Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation[J]. proceedings of the national academy of sciences of the united states of america,2010.
APA	Guo, Pengfei,Hu, Tianjing,Zhang, Juan,Jiang, Shanya,&Wang, Xiaochen.(2010).Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation.proceedings of the national academy of sciences of the united states of america.
MLA	Guo, Pengfei,et al."Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation".proceedings of the national academy of sciences of the united states of america (2010).