The chromatin remodeling complex NuRD establishes the poised state of   rRNA genes characterized by bivalent histone modifications and altered   nucleosome positions

doi:10.1073/pnas.1201262109

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	The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions
	Xie, Wenbing ; Ling, Te ; Zhou, Yonggang ; Feng, Weijun ; Zhu, Qiaoyun ; Stunnenberg, Henk G. ; Grummt, Ingrid ; Tao, Wei
刊名	proceedings of the national academy of sciences of the united states of america
	2012
关键词	poised chromatin cell differentiation epigenetic dynamics NoRC POLYMERASE-I TRANSCRIPTION NORC BINDING PROTEIN METHYLTRANSFERASE CHROMODOMAINS METHYLATION TERMINATION EXPRESSION MI-2-BETA
DOI	10.1073/pnas.1201262109
英文摘要	rRNA genes (rDNA) exist in two distinct epigenetic states, active promoters being unmethylated and marked by euchromatic histone modifications, whereas silent ones are methylated and exhibit heterochromatic features. Here we show that the nucleosome remodeling and deacetylation (NuRD) complex establishes a specific chromatin structure at rRNA genes that are poised for transcription activation. The promoter of poised rRNA genes is unmethylated, associated with components of the preinitiation complex, marked by bivalent histone modifications and covered by a nucleosome in the "off" position, which is refractory to transcription initiation. Repression of rDNA transcription in growth-arrested and differentiated cells correlates with elevated association of NuRD and increased levels of poised rRNA genes. Reactivation of transcription requires resetting the promoter-bound nucleosome into the "on" position by the DNA-dependent ATPase CSB (Cockayne syndrome protein B). The results uncover a unique mechanism by which ATP-dependent chromatin remodeling complexes with opposing activities establish a specific chromatin state and regulate transcription.; Multidisciplinary Sciences; SCI(E); PubMed; 27; ARTICLE; 21; 8161-8166; 109
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343416]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xie, Wenbing,Ling, Te,Zhou, Yonggang,et al. The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions[J]. proceedings of the national academy of sciences of the united states of america,2012.
APA	Xie, Wenbing.,Ling, Te.,Zhou, Yonggang.,Feng, Weijun.,Zhu, Qiaoyun.,...&Tao, Wei.(2012).The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions.proceedings of the national academy of sciences of the united states of america.
MLA	Xie, Wenbing,et al."The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions".proceedings of the national academy of sciences of the united states of america (2012).