Chaperone function and mechanism of small heat-shock proteins

doi:10.1093/abbs/gmt152

CORC > 北京大学 > 生命科学学院

	Chaperone function and mechanism of small heat-shock proteins
	Fu, Xinmiao
刊名	acta biochimica et biophysica sinica
	2014
关键词	protein quality control molecular chaperone small heat-shock protein protein aggregation oligomer ALPHA-B-CRYSTALLIN MYCOBACTERIUM-TUBERCULOSIS HSP16.3 SITE-DIRECTED MUTATIONS MOLTEN GLOBULE STATES C-TERMINAL EXTENSION ESCHERICHIA-COLI MOLECULAR CHAPERONE IN-VIVO SUBUNIT EXCHANGE A-CRYSTALLIN
DOI	10.1093/abbs/gmt152
英文摘要	Small heat-shock proteins (sHSPs) are ubiquitous ATP-independent molecular chaperones that play crucial roles in protein quality control in cells. They are able to prevent the aggregation and/or inactivation of various non-native substrate proteins and assist the refolding of these substrates independently or under the help of other ATP-dependent chaperones. Substrate recognition and binding by sHSPs are essential for their chaperone functions. This review focuses on what natural substrate proteins an sHSP protects and how it binds the substrates in cells under fluctuating conditions. It appears that sHSPs of prokaryotes, although being able to bind a wide range of cellular proteins, preferentially protect certain classes of functional proteins, such as translation-related proteins and metabolic enzymes, which may well explain why they could increase the resistance of host cells against various stresses. Mechanistically, the sHSPs of prokaryotes appear to possess numerous multi-type substrate-binding residues and are able to hierarchically activate these residues in a temperature-dependent manner, and thus act as temperature-regulated chaperones. The mechanism of hierarchical activation of substrate-binding residues is also discussed regarding its implication for eukaryotic sHSPs.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335768700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biophysics; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 8; REVIEW; fuxinmiao@pku.edu.cn; 5; 347-356; 46
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342745]
专题	生命科学学院
推荐引用方式 GB/T 7714	Fu, Xinmiao. Chaperone function and mechanism of small heat-shock proteins[J]. acta biochimica et biophysica sinica,2014.
APA	Fu, Xinmiao.(2014).Chaperone function and mechanism of small heat-shock proteins.acta biochimica et biophysica sinica.
MLA	Fu, Xinmiao."Chaperone function and mechanism of small heat-shock proteins".acta biochimica et biophysica sinica (2014).