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	Two-signal requirement for growth-promoting function of Yap in hepatocytes
	Su, Tian ; Bondar, Tanya ; Zhou, Xu ; Zhang, Cuiling ; He, Hang ; Medzhitov, Ruslan
刊名	elife
	2015
关键词	YES-ASSOCIATED PROTEIN STEM-CELL PROLIFERATION TUMOR-SUPPRESSOR PATHWAY ORGAN SIZE CONTROL LARGE GENE LISTS HIPPO PATHWAY HEPATOCELLULAR-CARCINOMA TEAD/TEF FAMILY ACTS DOWNSTREAM TGF-BETA
DOI	10.7554/eLife.02948
英文摘要	The transcriptional coactivator Yes-associated protein (Yap) promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation. Here we present evidence that Yap activation is insufficient to promote growth in the otherwise normal tissue. Using a mosaic mouse model, we demonstrate that Yap overexpression in a fraction of hepatocytes does not lead to their clonal expansion, as proliferation is counterbalanced by increased apoptosis. To shift the activity of Yap towards growth, a second signal provided by tissue damage or inflammation is required. In response to liver injury, Yap drives clonal expansion, suppresses hepatocyte differentiation and promotes a progenitor phenotype. These results suggest that Yap activation is insufficient to promote growth in the absence of a second signal thus coordinating tissue homeostasis and repair.; Biology; SCI(E); PubMed; 0; ARTICLE; Ruslan.Medzhitov@yale.edu; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341492]
专题	生命科学学院
推荐引用方式 GB/T 7714	Su, Tian,Bondar, Tanya,Zhou, Xu,et al. Two-signal requirement for growth-promoting function of Yap in hepatocytes[J]. elife,2015.
APA	Su, Tian,Bondar, Tanya,Zhou, Xu,Zhang, Cuiling,He, Hang,&Medzhitov, Ruslan.(2015).Two-signal requirement for growth-promoting function of Yap in hepatocytes.elife.
MLA	Su, Tian,et al."Two-signal requirement for growth-promoting function of Yap in hepatocytes".elife (2015).

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