Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish

doi:10.1242/jcs.167874

CORC > 北京大学 > 生命科学学院

	Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish
	Gao Hai ; Bu Ye ; Wu Qing ; Wang Xu ; Chang Nannan ; Lei Lei ; Chen Shilin ; Liu Dong ; Zhu Xiaojun ; Hu Keping ; Xiong Jing-Wei
刊名	journal of cell science
	2015
DOI	10.1242/jcs.167874
英文摘要	Rett syndrome (RTT) is a progressive neurological disorder caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MeCP2). The endogenous function of MeCP2 during neural differentiation is still unclear. Here we report that mecp2 is critical for brain development in zebrafish. Mecp2 was broadly expressed initially in embryos and enriched later in the brain. Either morpholino knockdown or genetic depletion of mecp2 inhibited neuronal differentiation, while its over-expression promoted neuronal differentiation, suggesting an essential role of mecp2 in directing neural precursors into differentiated neurons. Mechanistically, her2/hes5 was upregulated in mecp2 morphants in an Id1-dependent manner. Moreover, knockdown of either her2/hes5 or id1 fully rescued neuronal differentiation in mecp2 morphants. These results suggest that Mecp2 plays an important role in neural cell development by suppressing the Id1-Her2/Hes5 axis, and provide new evidence that embryonic neural defects contribute to the later motor and cognitive dysfunctions in RTT.? 2015. Published by The Company of Biologists Ltd.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357948900012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); PubMed; 5; ARTICLE; kphu@implad.ac.cn; jingwei_xiong@pku.edu.cn
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341244]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gao Hai,Bu Ye,Wu Qing,et al. Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish[J]. journal of cell science,2015.
APA	Gao Hai.,Bu Ye.,Wu Qing.,Wang Xu.,Chang Nannan.,...&Xiong Jing-Wei.(2015).Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish.journal of cell science.
MLA	Gao Hai,et al."Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish".journal of cell science (2015).