TALEN-mediated precise genome modification by homologous recombination   in zebrafish

doi:10.1038/NMETH.2374

CORC > 北京大学 > 生命科学学院

	TALEN-mediated precise genome modification by homologous recombination in zebrafish
	Zu, Yao ; Tong, Xiangjun ; Wang, Zhanxiang ; Liu, Da ; Pan, Ruochuan ; Li, Zhe ; Hu, Yingying ; Luo, Zhou ; Huang, Peng ; Wu, Qian ; Zhu, Zuoyan ; Zhang, Bo ; Lin, Shuo
刊名	自然方法
	2013
关键词	ZINC-FINGER NUCLEASES TARGETED GENE DISRUPTION DESIGN CELLS MICE
DOI	10.1038/NMETH.2374
英文摘要	We report gene targeting via homologous recombination in zebrafish. We co-injected fertilized eggs with transcription activator-like effector nuclease mRNAs and a donor vector with long homologous arms targeting the tyrosine hydroxylase (th) locus, and we observed effective gene modification that was transmitted through the germ line. We also successfully targeted two additional genes. Homologous recombination in zebrafish with a dsDNA donor expands the utility of this model organism.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000316851100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; SCI(E); PubMed; 137; ARTICLE; 4; 329-+; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319934]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zu, Yao,Tong, Xiangjun,Wang, Zhanxiang,et al. TALEN-mediated precise genome modification by homologous recombination in zebrafish[J]. 自然方法,2013.
APA	Zu, Yao.,Tong, Xiangjun.,Wang, Zhanxiang.,Liu, Da.,Pan, Ruochuan.,...&Lin, Shuo.(2013).TALEN-mediated precise genome modification by homologous recombination in zebrafish.自然方法.
MLA	Zu, Yao,et al."TALEN-mediated precise genome modification by homologous recombination in zebrafish".自然方法 (2013).