Suppression of endogenous gene silencing by bidirectional cytoplasmic   RNA decay in Arabidopsis

doi:10.1126/science.aaa2618

CORC > 北京大学 > 生命科学学院

	Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
	Zhang, Xinyan ; Zhu, Ying ; Liu, Xiaodan ; Hong, Xinyu ; Xu, Yang ; Zhu, Ping ; Shen, Yang ; Wu, Huihui ; Ji, Yusi ; Wen, Xing ; Zhang, Chen ; Zhao, Qiong ; Wang, Yichuan ; Lu, Jian ; Guo, Hongwei
刊名	science
	2015
关键词	ETHYLENE GAS TRANSCRIPTION PROTEINS ETHYLENE-INSENSITIVE3 INTERFERENCE BIOGENESIS RESPONSES TURNOVER PLANTS
DOI	10.1126/science.aaa2618
英文摘要	Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352079500040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 32; ARTICLE; hongweig@pku.edu.cn; 6230; 120-123; 348
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/319913]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Xinyan,Zhu, Ying,Liu, Xiaodan,et al. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis[J]. science,2015.
APA	Zhang, Xinyan.,Zhu, Ying.,Liu, Xiaodan.,Hong, Xinyu.,Xu, Yang.,...&Guo, Hongwei.(2015).Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis.science.
MLA	Zhang, Xinyan,et al."Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis".science (2015).