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	Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors
	Yan, Y ; Cai, J ; Fu, P ; Layfield, S ; Ferraro, T ; Kumagai, J ; Sudo, S ; Tang, JG ; Giannakis, E ; Tregear, GW ; Wade, JD ; Bathgate, RAD
	2005
关键词	relaxin LGR7 LGR8 7BP Ciphergen SELDI-MS
英文摘要	The ectodomains of both the relaxin (LGR7) and the INSL3 (LGR8) receptors can be expressed on the cell surface using only a single transmembrane domain. These membrane-anchored proteins retain the ability to bind relaxin and can be cleaved from the cell surface. The subsequent LGR7 protein, 7BP, binds relaxin and can act as a functional relaxin antagonist. By contrast, the equivalent LGR8 protein 8BP does not bind relaxin or antagonize LGR8 activity. The 7BP protein has been successfully immobilized onto chemically derivatized surfaces for the capture of relaxin peptides and subsequent identification via SELDI-MS analysis.; Biochemistry & Molecular Biology; Endocrinology & Metabolism; Multidisciplinary Sciences; Physiology; SCI(E); CPCI-S(ISTP); 13
语种	英语
DOI标识	10.1196/annals.1282.007
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/254208]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yan, Y,Cai, J,Fu, P,et al. Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors. 2005-01-01.

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