Small-molecule inhibition of Aurora kinases triggers spindle   checkpoint-independent apoptosis in cancer cells

doi:10.1016/j.bcp.2007.11.007

CORC > 北京大学 > 生命科学学院

	Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells
	Sun, Lei ; Li, Denywen ; Dong, Xin ; Yu, Haiyang ; Dong, Jin-Tang ; Zhang, Chuanmao ; Lu, Xianyu ; Zhou, Jun
刊名	biochemical pharmacology
	2008
关键词	aurora kinases breast cancer spindle checkpoint mitosis apoptosis ASSEMBLY CHECKPOINT MITOTIC CHECKPOINT ANTICANCER DRUGS MITOSIS DEATH SUSCEPTIBILITY SENSITIVITY RESISTANCE ANEUPLOIDY POTENT
DOI	10.1016/j.bcp.2007.11.007
英文摘要	Aurora kinases are key regulators of mitotic progression and have also been implicated in tumorigenesis. Small molecules that inhibit Aurora kinases have shown impressive anticancer activity in preclinical studies and are currently under clinical evaluation. In this study, our data show that suppression of Aurora activity with a specific inhibitor prevents the proliferation of breast cancer cells. Molecular modeling studies indicate that the Aurora inhibitor suppresses Aurora activity by competitive displacement of ATP. Mechanistically, the Aurora inhibitor causes the accumulation of multinucleated cells, leading to profound apoptosis in the absence of caspase-3 activity. Further studies show that the sensitivity of cancer cells to the Aurora inhibitor is independent of the spindle checkpoint. in addition, the Aurora inhibitor acts synergistically with the vinca alkaloids but not with the taxanes in inhibiting cell proliferation and inducing apoptosis. These results suggest that Aurora inhibitors might be effective in spindle checkpoint-defective cancer cells and a combination of Aurora inhibitors with the vinca alkaloids is a promising approach for cancer chemotherapy. (c) 2007 Elsevier Inc. All rights reserved.; Pharmacology & Pharmacy; SCI(E); 10; ARTICLE; 5; 1027-1034; 75
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/249216]
专题	生命科学学院
推荐引用方式 GB/T 7714	Sun, Lei,Li, Denywen,Dong, Xin,et al. Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells[J]. biochemical pharmacology,2008.
APA	Sun, Lei.,Li, Denywen.,Dong, Xin.,Yu, Haiyang.,Dong, Jin-Tang.,...&Zhou, Jun.(2008).Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells.biochemical pharmacology.
MLA	Sun, Lei,et al."Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells".biochemical pharmacology (2008).