MiR-206 decreases brain-derived neurotrophic factor levels in a   transgenic mouse model of Alzheimer&apos;s disease

doi:10.1007/s12264-013-1419-7

CORC > 北京大学 > 生命科学学院

	MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease
	Tian, Ning ; Cao, Zeyuan ; Zhang, Yan
刊名	神经科学通报
	2014
关键词	miR-206 brain-derived neurotrophic factor APP/PS1 cell death Alzheimer&apos MILD COGNITIVE IMPAIRMENT INDUCED ARC EXPRESSION INTRACELLULAR AMYLOID TOXICITY HUMAN PRIMARY NEURONS CORTICAL-NEURONS SIGNALING PATHWAYS BDNF BETA PROTEIN MICRORNAS s disease
DOI	10.1007/s12264-013-1419-7
英文摘要	MicroRNA alterations have been reported in patients with Alzheimer's disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.; Neurosciences; SCI(E); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 7; ARTICLE; yanzhang@pku.edu.cn; 2,SI; 191-197; 30
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/214948]
专题	生命科学学院
推荐引用方式 GB/T 7714	Tian, Ning,Cao, Zeyuan,Zhang, Yan. MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease[J]. 神经科学通报,2014.
APA	Tian, Ning,Cao, Zeyuan,&Zhang, Yan.(2014).MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease.神经科学通报.
MLA	Tian, Ning,et al."MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease".神经科学通报 (2014).