Effects of galanin on wide-dynamic range neuron activity in the spinal   dorsal horn of rats with sciatic nerve ligation

doi:10.1016/S0167-0115(00)00127-0

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	Effects of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats with sciatic nerve ligation
	Xu, SL ; Zhang, YP ; Lundeberg, T ; Yu, LC
刊名	正规肽
	2000
关键词	galanin receptor extracellular recording neuron discharge frequency mononeuropathy nociception SENSORY NEURONS PERIPHERAL MONONEUROPATHY INTRATHECAL GALANIN PAIN CORD INJURY MODEL IMMUNOREACTIVITY HYPERALGESIA RESPONSES
DOI	10.1016/S0167-0115(00)00127-0
英文摘要	Galanin is a 29-amino acid peptide with a suggested role in nociception. The effect of galanin on wide-dynamic range neuron discharge frequency in rats with nerve ligation, used as a model of neurogenic pain, was investigated by extracellular recording methods. Seven to 14 days after sciatic nerve ligation, 0.1, 0.5 or 1 nmol of galanin was administered directly on the dorsal surface of the L3-L5 spinal cord of rats with sciatic nerve ligation. It was found that galanin inhibited the activity of wide-dynamic range neurons dose-dependently, an effect was more pronounced in sciatic nerve ligated rats than intact rats. Furthermore, when 1 nmol of galantide, the galanin antagonist, was administered on the dorsal surface of the L3-L5 spinal cord, the wide-dynamic range neuron discharge frequency increased significantly. The results suggest that galanin plays an important role in the modulation of presumed nociception in mononeuropathy. (C) 2000 Elsevier Science B.V. All rights reserved.; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 15; ARTICLE; 1-3; 19-23; 95
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200609]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, SL,Zhang, YP,Lundeberg, T,et al. Effects of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats with sciatic nerve ligation[J]. 正规肽,2000.
APA	Xu, SL,Zhang, YP,Lundeberg, T,&Yu, LC.(2000).Effects of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats with sciatic nerve ligation.正规肽.
MLA	Xu, SL,et al."Effects of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats with sciatic nerve ligation".正规肽 (2000).