Ce-wts-1 plays important roles in Caenorhabditis elegans development

doi:10.1016/j.febslet.2009.09.002

CORC > 北京大学 > 生命科学学院

	Ce-wts-1 plays important roles in Caenorhabditis elegans development
	Cai, Qingchun ; Wang, Wenqing ; Gao, Ying ; Yang, Yongfei ; Zhu, Zuoyan ; Fan, Qichang
刊名	欧洲生化学会联合会快报
	2009
关键词	Warts family Ce-wts-1 TGF-beta Development Membrane Caenorhabditis elegans REGULATES BODY-SIZE C-ELEGANS HOMEODOMAIN PROTEIN SIGNALING PATHWAY LIFE-SPAN KINASE HOMOLOG ENCODES GROWTH PHOSPHORYLATION
DOI	10.1016/j.febslet.2009.09.002
英文摘要	The Hippo-Warts pathway defines a novel signaling cascade involved in organ size control and tumor suppression. However, the developmental function of this pathway is less understood. Here we report that the Caenorhabditis elegans homolog of Warts, Ce-wts-1, plays important roles during worm development. The null allele of Ce-wts-1 causes L1 lethality. Partial loss of Ce-wts-1 function by RNAi reveals that Ce-wts-1 is involved in many developmental processes such as larval development, growth rate regulation, gut granule formation, pharynx development, dauer formation, life-span and body length control. Genetic analyses show that Ce-wts-1 functions synergistically with the TGF-beta Sma/Mab pathway to regulate body length. In addition, CE-WTS-1::GFP is enriched near the inner cell membrane, implying its possible membrane-related function. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; Biochemistry & Molecular Biology; Biophysics; Cell Biology; SCI(E); PubMed; 4; ARTICLE; 19; 3158-3164; 583
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/196730]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cai, Qingchun,Wang, Wenqing,Gao, Ying,et al. Ce-wts-1 plays important roles in Caenorhabditis elegans development[J]. 欧洲生化学会联合会快报,2009.
APA	Cai, Qingchun,Wang, Wenqing,Gao, Ying,Yang, Yongfei,Zhu, Zuoyan,&Fan, Qichang.(2009).Ce-wts-1 plays important roles in Caenorhabditis elegans development.欧洲生化学会联合会快报.
MLA	Cai, Qingchun,et al."Ce-wts-1 plays important roles in Caenorhabditis elegans development".欧洲生化学会联合会快报 (2009).