Neuronal necrosis is regulated by a conserved chromatin-modifying   cascade

doi:10.1073/pnas.1413644111

CORC > 北京大学 > 生命科学学院

	Neuronal necrosis is regulated by a conserved chromatin-modifying cascade
	Liu, Kai ; Ding, Lianggong ; Li, Yuhong ; Yang, Hui ; Zhao, Chunyue ; Lei, Ye ; Han, Shuting ; Tao, Wei ; Miao, Dengshun ; Steller, Hermann ; Welsh, Michael J. ; Liu, Lei
刊名	proceedings of the national academy of sciences of the united states of america
	2014
关键词	neurodegeneration epigenetics histone modification H3K4me3 aging CEREBRAL-ARTERY OCCLUSION CELL-DEATH HISTONE H3 C-ELEGANS MECHANISMS ACTIVATION DROSOPHILA POLYCOMB STROKE KINASES
DOI	10.1073/pnas.1413644111
英文摘要	Neuronal necrosis induced by calcium overload causes devastating brain dysfunction in diseases such as stroke and brain trauma. It has been considered a stochastic event lacking genetic regulation, and pharmacological means to suppress neuronal necrosis are lacking. Using a Drosophila model of calcium overloading, we found JIL-1/mitogen- and stress-activated protein kinase 1/2 is a regulator of neuronal necrosis through phosphorylation of histone H3 serine 28 (H3S28ph). Further, we identified its downstream events including displacement of polycomb repressive complex 1 (PRC1) and activation of Trithorax (Trx). To test the role of JIL-1/PRC1/Trx cascade in mammals, we studied the necrosis induced by glutamate in rat cortical neuron cultures and rodent models of brain ischemia and found the cascade is activated in these conditions and inhibition of the cascade suppresses necrosis in vitro and in vivo. Together, our research demonstrates that neuronal necrosis is regulated by a chromatin-modifying cascade, and this discovery may provide potential therapeutic targets and biomarkers for neuronal necrosis.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341988200066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); PubMed; 9; ARTICLE; michael-welsh@uiowa.edu; leiliu@pku.edu.cn; 38; 13960-13965; 111
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189154]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Kai,Ding, Lianggong,Li, Yuhong,et al. Neuronal necrosis is regulated by a conserved chromatin-modifying cascade[J]. proceedings of the national academy of sciences of the united states of america,2014.
APA	Liu, Kai.,Ding, Lianggong.,Li, Yuhong.,Yang, Hui.,Zhao, Chunyue.,...&Liu, Lei.(2014).Neuronal necrosis is regulated by a conserved chromatin-modifying cascade.proceedings of the national academy of sciences of the united states of america.
MLA	Liu, Kai,et al."Neuronal necrosis is regulated by a conserved chromatin-modifying cascade".proceedings of the national academy of sciences of the united states of america (2014).