Association between variants of zinc finger genes and psychiatric   disorders: Systematic review and meta-analysis

doi:10.1016/j.schres.2015.01.036

CORC > 北京大学 > 生命科学学院

	Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis
	Sun, Yan ; Hu, Die ; Liang, Jie ; Bao, Yan-Ping ; Meng, Shi-Qiu ; Lu, Lin ; Shi, Jie
刊名	schizophrenia research
	2015
关键词	Psychiatric disorders ZNF804A Zinc finger genes Meta-analysis Genetic variants SUPPORTED PSYCHOSIS VARIANT GENOME-WIDE ASSOCIATION DORSOLATERAL PREFRONTAL CORTEX AUTISM SPECTRUM DISORDER CARDIO-FACIAL SYNDROME DEFAULT-MODE NETWORK ZNF804A GENE BIPOLAR DISORDER SCHIZOPHRENIA SUSCEPTIBILITY POLYMORPHISM RS1344706
DOI	10.1016/j.schres.2015.01.036
英文摘要	Psychiatric disorders have a negative impact on society and human lives. Genetic factors are involved in the occurrence and development of psychiatric diseases. ZNF804A has been identified as one of the most compelling risk genes associated with broad phenotypes related to psychosis. We conducted a systematic meta-analysis and reviewed ZNF804A variants in psychosis-related disorders, including schizophrenia, bipolar disorder, and attention-deficit hyperactivity disorder. We also summarized the association between other zinc finger protein genes (ZNFs) and psychiatric diseases. The meta-analysis included a total of six variants of ZNF804A and three variants of other ZNFs (ZDHHC8 and ZKSCAN4), and the effects of ZNF variants on neurocognition and neuroimaging phenotypes were reviewed. The biological functions of these variants are also presented. We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity. The main brain area regulated by ZNF804A rs1344706 was the dorsolateral prefrontal cortex. The effect of ZNF804A variants on cognition did not display consistency with different diseases or methodologies. These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes. (C) 2015 Elsevier B.V. All rights reserved.; Psychiatry; SCI(E); PubMed; SSCI; 0; ARTICLE; shijie@bjmu.edu.cn; 1-3; 124-137; 162
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188318]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Sun, Yan,Hu, Die,Liang, Jie,et al. Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis[J]. schizophrenia research,2015.
APA	Sun, Yan.,Hu, Die.,Liang, Jie.,Bao, Yan-Ping.,Meng, Shi-Qiu.,...&Shi, Jie.(2015).Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis.schizophrenia research.
MLA	Sun, Yan,et al."Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis".schizophrenia research (2015).